Asymmetric bioreduction of cyclohexylphenyl ketone to its corresponding alcohol (+) cyclohexylphenyl alcohol by the yeast Candida magnoliae MY 1785

被引：12

作者：

Chartrain, M ^{[1
]}

Mathre, D ^{[1
]}

Reamer, RA ^{[1
]}

Patel, S ^{[1
]}

Shinkai, I ^{[1
]}

Greasham, R ^{[1
]}

机构：

[1] MERCK & CO INC,MERCK SHARP & DOHME RES LABS,DEPT PROC RES,RAHWAY,NJ 07065

来源：

JOURNAL OF FERMENTATION AND BIOENGINEERING | 1997年 / 83卷 / 04期

关键词：

asymmetric synthesis; biocatalysis; biotransformation; bioconversion; fermentation;

D O I：

10.1016/S0922-338X(97)80150-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The screening of 129 fungal and yeasts strains yielded Candida magnoliae MY 1785 as a suitable biocatalyst for the asymmetric bioreduction of cyclohexylphenyl ketone to its corresponding alcohol. Preparative amounts of pure alcohol were prepared and purified. Polarimetry and chiral HPLC analyses indicated that C. magnoliae produced the (+) cyclohexylphenyl alcohol with an enantiomeric excess of 75%. A 55% bioconversion yield was achieved at the preparative scale.

引用

页码：395 / 396

页数：2

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