In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp.

被引：213

作者：

Arikan, S ^{[1
]}

Lozano-Chiu, M ^{[1
]}

Paetznick, V ^{[1
]}

Rex, JH ^{[1
]}

机构：

[1] Univ Texas, Sch Med, Ctr Study Emerging & Reemerging Pathogens, Dept Internal Med,Div Infect Dis, Houston, TX 77030 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 01期

关键词：

D O I：

10.1128/AAC.46.1.245-247.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We investigated the in vitro interaction of caspofungin and amphotericin B for clinical isolates of Aspergillus and Fusarium. Synergy tests were performed using the checkerboard method and following the NCCLS M38-P guidelines in Antibiotic Medium 3 broth supplemented to 2% glucose. Antagonism was not observed for any of the isolates tested. Caspofungin and amphotericin B were synergistic or synergistic to additive for at least half of the isolates.

引用

页码：245 / 247

页数：3

共 10 条

[1] Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice
Abruzzo, GK
Gill, CJ
Flattery, AM
Kong, L
Leighton, C
Smith, JG
Pikounis, VB
Bartizal, K
Rosen, H
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (09) : 2310 - 2318
[2] Evaluation of the echinocandin antifungal MK-0991 (L-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis
Abruzzo, GK
Flattery, AM
Gill, CJ
Kong, L
Smith, JG
Pikounis, VB
Balkovec, JM
Bouffard, AF
Dropinski, JF
Rosen, H
Kropp, H
Bartizal, K
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (11) : 2333 - 2338
[3] Microdilution susceptibility testing of amphotericin B, itraconazole, and voriconazole against clinical isolates of Aspergillus and Fusarium species
Arikan, S
Lozano-Chiu, M
Paetznick, V
Nangia, S
Rex, JH
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (12) : 3946 - 3951
[4] In vitro susceptibility testing methods for caspofungin against Aspergillus and Fusarium isolates
Arikan, S
Lozano-Chiu, M
Paetznick, V
Rex, JH
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (01) : 327 - 330
[5] Quantitation of Candida albicans ergosterol content improves the correlation between in vitro antifungal susceptibility test results and in vivo outcome after fluconazole treatment in a murine model of invasive candidiasis
Arthington-Skaggs, BA
Warnock, DW
Morrison, CJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (08) : 2081 - 2085
[6] Pneumocandin L-743,872 enhances the activities of amphotericin B and fluconazole against Cryptococcus neoformans in vitro
Franzot, SP
Casadevall, A
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (02) : 331 - 336
[7] MORPHOLOGICAL EFFECTS OF LIPOPEPTIDES AGAINST ASPERGILLUS-FUMIGATUS CORRELATE WITH ACTIVITIES AGAINST (1,3)-BETA-D-GLUCAN SYNTHASE
KURTZ, MB
HEATH, IB
MARRINAN, J
DREIKORN, S
ONISHI, J
DOUGLAS, C
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (07) : 1480 - 1489
[8] National Committee for Clinical Laboratory Standards, 1998, M38P NAT COMM CLIN L
[9] Optimizing the correlation between results of testing in vitro and therapeutic outcome in vivo for fluconazole by testing critical isolates in a murine model of invasive candidiasis
Rex, JH
Nelson, PW
Paetznick, VL
Lozano-Chiu, M
Espinel-Ingroff, A
Anaissie, EJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (01) : 129 - 134
[10] DETECTION OF AMPHOTERICIN B-RESISTANT CANDIDA ISOLATES IN A BROTH-BASED SYSTEM
REX, JH
COOPER, CR
MERZ, WG
GALGIANI, JN
ANAISSIE, EJ
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (04) : 906 - 909

← 1 →