Sexual-stage antibody responses to P-falciparum in endemic populations

被引:45
作者
Bousema, JT
Drakeley, CJ
Sauerwein, RW
机构
[1] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, NL-6500 HB Nijmegen, Netherlands
[2] Joint Malaria Programme, Moshi, Tanzania
基金
英国惠康基金;
关键词
malaria; Plasmodium falciparum; gametocyte; sexual stage immunity; transmission; Pfs230; Pfs48/45;
D O I
10.2174/156652406776055140
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Gametocytes and sporogonic stages are responsible for the spread of disease and drug resistance in the population. Sexual stage immunity affects the infectiousness of gametocytes to mosquitoes. Specific antibodies including anti-Pfs48/45 and anti-Pfs230 antibodies are found in individuals with limited prior exposure to malaria. Sexual stage antibodies are rapidly acquired after infection and are relatively prevalent in gametocytaemic individuals. Functional transmission reducing activity (TRA) is found after primary infections and in young children and appears to depend on recent rather than cumulative exposure to gametocytes. Exposure to gametocytes decreases with age most likely as a consequence of the acquisition of asexual-stage immunity that controls asexual parasite density and consequently gametocytaemia. This results in lower exposure to the antigenic load of gametocytes in semi-immune individuals. Since sexual stage immunity is probably short-lived in the absence of gametocytes, we hypothesize that sexual stage immunity will wane, resulting in low antibody and TRA prevalences in clinically semi-immune carriers.
引用
收藏
页码:223 / 229
页数:7
相关论文
共 87 条
[1]   Antibodies to Plasmodium falciparum rifin proteins are associated with rapid parasite clearance and asymptomatic infections [J].
Abdel-Latif, MS ;
Dietz, K ;
Issifou, S ;
Kremsner, PG ;
Klinkert, MQ .
INFECTION AND IMMUNITY, 2003, 71 (11) :6229-6233
[2]   Immunity to the sexual stages of Plasmodium falciparum in mothers, neonates and infants subject to intense and perennial malarial transmission [J].
Akim, NIJ ;
Urassa, H ;
Drakeley, CJ ;
Sauerwein, RW ;
Kitua, AY .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 2002, 96 (07) :735-737
[3]   SEXUAL-DIFFERENTIATION IN MALARIA PARASITES [J].
ALANO, P ;
CARTER, R .
ANNUAL REVIEW OF MICROBIOLOGY, 1990, 44 :429-449
[4]   EVIDENCE FOR SPECIFIC SUPPRESSION OF GAMETOCYTEMIA BY PLASMODIUM-FALCIPARUM IN RESIDENTS OF HYPERENDEMIC IRIAN JAYA [J].
BAIRD, JK ;
JONES, TR ;
PURNOMO ;
MASBAR, S ;
RATIWAYANTO, S ;
LEKSANA, B .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1991, 44 (02) :183-190
[5]   Humoral immune responses in Gambians to Pfs16, an immunodominant, Plasmodium falciparum integral membrane protein [J].
Baker, DA ;
Drakeley, CJ ;
Ong, CSL ;
Lulat, AGMI ;
Greenwood, BM ;
Targett, GAT .
PARASITE IMMUNOLOGY, 1996, 18 (10) :527-533
[6]   Comparison of artificial membrane feeding with direct skin feeding to estimate infectiousness of Plasmodium falciparum gametocyte carriers to mosquitoes [J].
Bonnet, S ;
Gouagna, C ;
Safeukui, I ;
Meunier, JY ;
Boudin, C .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2000, 94 (01) :103-106
[7]   EPIDEMIOLOGY OF PLASMODIUM-FALCIPARUM IN A RICE FIELD AND A SAVANNA AREA IN BURKINA-FASO - SEASONAL FLUCTUATIONS OF GAMETOCYTAEMIA AND MALARIAL INFECTIVITY [J].
BOUDIN, C ;
LYANNAZ, J ;
BOSSENO, MF ;
CARNEVALE, P ;
AMBROISETHOMAS, P .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 1991, 85 (04) :377-385
[8]   HIGH HUMAN MALARIAL INFECTIVITY TO LABORATORY-BRED ANOPHELES-GAMBIAE IN A VILLAGE IN BURKINA-FASO [J].
BOUDIN, C ;
OLIVIER, M ;
MOLEZ, JF ;
CHIRON, JP ;
AMBROISETHOMAS, P .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1993, 48 (05) :700-706
[9]   Plasmodium falciparum transmission blocking immunity under conditions of low and high endemicity in Cameroon [J].
Boudin, C ;
van der Kolk, M ;
Tchuinkam, T ;
Gouagna, C ;
Bonnet, S ;
Safeukui, I ;
Mulder, B ;
Meunier, JY ;
Verhave, JP .
PARASITE IMMUNOLOGY, 2004, 26 (02) :105-110
[10]  
BOUSEMA JT, 2006, IN PRESS AM J TROP M