Activities of IRF-1

被引：230

作者：

Kröger, A ^{[1
]}

Köster, M ^{[1
]}

Schroeder, K ^{[1
]}

Hauser, H ^{[1
]}

Mueller, PP ^{[1
]}

机构：

[1] Gesell Biotechnol Forsch mbH, Dept Gene Regulat & Differentiat, GBF, D-38124 Braunschweig, Germany

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 2002年 / 22卷 / 01期

关键词：

D O I：

10.1089/107999002753452610

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interferon (IFN) regulatory factor-1 (IRF-1) was isolated by virtue of its affinity to specific DNA sequences in the IFN-beta promoter that mediate virus responsiveness. IRF-1 was the first factor identified of the IRF family and was most extensively characterized at the molecular level. Also, its physiologic role in host defense against pathogens, tumor prevention, and development of the immune system was investigated in detail. Even though some of the functions first associated with IRF-1 were later found to be mediated in part or predominantly by other activators of the IRF family of transcription factors, IRF-1 has remained a central paradigm in the transcriptional regulation of the IFN response.

引用

页码：5 / 14

页数：10

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