NMDA Receptors Pattern Early Activity in the Developing Barrel Cortex In Vivo

被引:69
作者
Minlebaev, Marat [1 ]
Ben-Ari, Yehezkiel [1 ]
Khazipov, Roustem [1 ]
机构
[1] Univ Mediterreneen, INSERM, U901, Mediterranean Inst Neurobiol, Marseille, France
关键词
delta-brush; delta waves; electroencephalography; neonate; NMDA; rat; RAT SOMATOSENSORY CORTEX; EARLY NEOCORTICAL DEVELOPMENT; CRITICAL PERIOD PLASTICITY; LONG-TERM POTENTIATION; EARLY MOTOR-ACTIVITY; THALAMOCORTICAL SYNAPSES; VISUAL-CORTEX; SILENT SYNAPSES; DEVELOPING HIPPOCAMPUS; SYNAPTIC PLASTICITY;
D O I
10.1093/cercor/bhn115
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
N-methyl-D-aspartate (NMDA) type of glutamate receptors play an important role in activity-dependent plasticity in the developing cortex. However, the physiological patterns of cortical activity that activate NMDA receptors in vivo remain largely unknown. We performed full-band recordings from the barrel cortex of neonatal rats in vivo and found that the dominant pattern of the early activity, network driven spindle bursts, are associated with large amplitude NMDA receptor-dependent delta waves. The major sink of delta waves was in the dense cortical plate, which coincided with the sinks of sensory-evoked responses as well as fast spindle-burst oscillations. Pharmacological analysis revealed major contributions from NMDA and alpha-aminopropionate (AMPA) type of glutamate receptors in the generation of delta waves, whereas fast oscillations primarily involved only AMPA receptors. Our results suggest that the 2 component spindle burst is generated by rhythmic, presumably thalamocortical, synaptic input which entrains an AMPA receptor-mediated fast oscillation and who's summation generates an NMDA and AMPA receptor mediated delta wave. The massive summation of thalamocortical activity during the spindle bursts thus provides a long time window for co-incident activation of cortical neurons by the thalamocortical cells which may contribute to the formation of thalamocortical synapses in the barrel cortex during the critical period of developmental plasticity.
引用
收藏
页码:688 / 696
页数:9
相关论文
共 100 条
[1]   THE EEG OF THE EARLY PREMATURE [J].
ANDERSON, CM ;
TORRES, F ;
FAORO, A .
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY, 1985, 60 (02) :95-105
[2]  
[Anonymous], 1992, ATLAS NEONATAL ELECT
[3]   NMDA receptors regulate developmental gap junction uncoupling via CREB signaling [J].
Arumugam, H ;
Liu, XH ;
Colombo, PJ ;
Corriveau, RA ;
Belousov, AB .
NATURE NEUROSCIENCE, 2005, 8 (12) :1720-1726
[4]   Developmental changes in AMPA and kainate receptor-mediated quantal transmission at thalamocortical synapses in the barrel cortex [J].
Bannister, NJ ;
Benke, TA ;
Mellor, J ;
Scott, H ;
Gürdal, E ;
Crabtree, JW ;
Isaac, JTR .
JOURNAL OF NEUROSCIENCE, 2005, 25 (21) :5259-5271
[5]   NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses [J].
Barth, AL ;
Malenka, RC .
NATURE NEUROSCIENCE, 2001, 4 (03) :235-236
[6]   GABA: A pioneer transmitter that excites immature neurons and generates primitive oscillations [J].
Ben-Ari, Yehezkel ;
Gaiarsa, Jean-Luc ;
Tyzio, Roman ;
Khazipov, Rustem .
PHYSIOLOGICAL REVIEWS, 2007, 87 (04) :1215-1284
[7]   GIANT SYNAPTIC POTENTIALS IN IMMATURE RAT CA3 HIPPOCAMPAL-NEURONS [J].
BENARI, Y ;
CHERUBINI, E ;
CORRADETTI, R ;
GAIARSA, JL .
JOURNAL OF PHYSIOLOGY-LONDON, 1989, 416 :303-325
[8]   DUAL MECHANISMS OF TWITCHING DURING SLEEP IN NEONATAL RATS [J].
BLUMBERG, MS ;
LUCAS, DE .
BEHAVIORAL NEUROSCIENCE, 1994, 108 (06) :1196-1202
[9]   Optical imaging of the intrinsic signal as a measure of cortical plasticity in the mouse [J].
Cang, JH ;
Kalatsky, VA ;
Löwel, S ;
Stryker, MP .
VISUAL NEUROSCIENCE, 2005, 22 (05) :685-691
[10]   ACTIVITY-DEPENDENT DECREASE IN NMDA RECEPTOR RESPONSES DURING DEVELOPMENT OF THE VISUAL-CORTEX [J].
CARMIGNOTO, G ;
VICINI, S .
SCIENCE, 1992, 258 (5084) :1007-1011