The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Study Protocol

被引：100

作者：

Woo, Daniel ^{[1
]}

Rosand, Jonathan ^{[2
]}

Kidwell, Chelsea ^{[3
]}

McCauley, Jacob L. ^{[4
]}

Osborne, Jennifer ^{[1
]}

Brown, Mark W. ^{[5
]}

West, Sandra E. ^{[4
]}

Rademacher, Eric W. ^{[6
]}

Waddy, Salina ^{[7
]}

Roberts, Jamie N. ^{[7
]}

Koch, Sebastian ^{[8
,11
]}

Gonzales, Nicole R. ^{[9
]}

Sung, Gene ^{[10
]}

Kittner, Steven J.

Birnbaum, Lee ^{[12
]}

Frankel, Michael ^{[1
]}

Testai, Fernando Daniel ^{[14
]}

Hall, Christiana E. ^{[15
]}

Elkind, Mitchell S. V. ^{[16
]}

Flaherty, Matthew ^{[13
]}

Coull, Bruce ^{[17
]}

Chong, Ji Y. ^{[18
]}

Warwick, Tanya ^{[19
]}

Malkoff, Marc ^{[20
]}

James, Michael L. ^{[21
]}

Ali, Latisha K. ^{[22
]}

Worrall, Bradford B. ^{[23
]}

Jones, Floyd ^{[12
]}

Watson, Tiffany ^{[24
]}

Leonard, Anne ^{[12
]}

Martinez, Rebecca ^{[9
]}

Sacco, Ralph I. ^{[8
]}

Langefeld, Carl D. ^{[5
]}

机构：

[1] Univ Cincinnati, Coll Med, Cincinnati, OH 45267 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Boston, MA USA

[3] Georgetown Univ, Med Ctr, Dept Neurol, Washington, DC 20007 USA

[4] Univ Miami, John P Hussman Inst Human Genom, Coral Gables, FL 33124 USA

[5] Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Winston Salem, NC USA

[6] Univ Cincinnati, Inst Policy Res, Cincinnati, OH 45267 USA

[7] NINDS, Bethesda, MD 20892 USA

[8] Univ Miami, Miller Sch Med, Coral Gables, FL 33124 USA

[9] Univ Texas Med Sch Houston, Houston, TX USA

[10] Univ So Calif, Neurocrit Care & Stroke Div, Los Angeles, CA USA

[11] Univ Maryland, Baltimore Vet Adm Med Ctr, Baltimore, MD 21201 USA

[12] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[13] Emory Univ, Grady Mem Hosp, Atlanta, GA 30322 USA

[14] Univ Illinois, Chicago Med Ctr, Chicago, IL 60680 USA

[15] Univ Texas SW Med Ctr Dallas, Dept Neurol & Neurotherapeut, Dallas, TX 75390 USA

[16] Columbia Univ, New York, NY USA

[17] Univ Arizona, Tucson, AZ USA

[18] St Lukes Roosevelt Hosp, New York, NY USA

[19] Univ Calif San Francisco, Fresno, CA USA

[20] Univ New Mexico, Albuquerque, NM 87131 USA

[21] Duke Univ, Dept Anesthesiol, Durham, NC USA

[22] Univ Calif Los Angeles, Los Angeles, CA USA

[23] Univ Virginia, Dept Neurol & Publ Hlth Sci, Charlottesville, VA USA

[24] Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA

来源：

STROKE | 2013年 / 44卷 / 10期

关键词：

cerebral hemorrhage; genetics; genomics; hypertension; minority groups; risk factors; stroke; QUALITY-OF-LIFE; COGNITIVE STATUS; STROKE; ADMIXTURE; BLACKS; WHITES; RISK; EUROQOL; PANEL;

D O I：

10.1161/STROKEAHA.113.002332

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Purpose Epidemiological studies of intracerebral hemorrhage (ICH) have consistently demonstrated variation in incidence, location, age at presentation, and outcomes among non-Hispanic white, black, and Hispanic populations. We report here the design and methods for this large, prospective, multi-center case-control study of ICH. Methods The Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) study is a multi-center, prospective case-control study of ICH. Cases are identified by hot-pursuit and enrolled using standard phenotype and risk factor information and include neuroimaging and blood sample collection. Controls are centrally identified by random digit dialing to match cases by age (5 years), race, ethnicity, sex, and metropolitan region. Results As of March 22, 2013, 1655 cases of ICH had been recruited into the study, which is 101.5% of the target for that date, and 851 controls had been recruited, which is 67.2% of the target for that date (1267 controls) for a total of 2506 subjects, which is 86.5% of the target for that date (2897 subjects). Of the 1655 cases enrolled, 1640 cases had the case interview entered into the database, of which 628 (38%) were non-Hispanic black, 458 (28%) were non-Hispanic white, and 554 (34%) were Hispanic. Of the 1197 cases with imaging submitted, 876 (73.2%) had a 24 hour follow-up CT available. In addition to CT imaging, 607 cases have had MRI evaluation. Conclusions The ERICH study is a large, case-control study of ICH with particular emphasis on recruitment of minority populations for the identification of genetic and epidemiological risk factors for ICH and outcomes after ICH.

引用

页码：E120 / E125

页数：6

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