Interferon γ:: a crucial role in the function of induced regulatory T cells in vivo

被引：173

作者：

Wood, KJ ^{[1
]}

Sawitzki, B

机构：

[1] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Surg, Transplantat Res Immunol Grp, Oxford OX3 9DU, England

[2] Inst Med Immunol, Charite, D-10117 Berlin, Germany

来源：

TRENDS IN IMMUNOLOGY | 2006年 / 27卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.it.2006.02.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferon (IFN)gamma can have paradoxical functions, eliciting inflammatory T helper 1 (Th1)-driven immune responses in some circumstances, and enabling induced regulatory T (Treg) cells to control immune responses in others. Here, we propose a model in which IFN gamma produced rapidly and only transiently by induced Treg cells is crucial to their function in vivo. This early production of IFN gamma by induced Treg cells during an immune response can directly inhibit the activation and proliferation of IFN gamma R1- and IFN gamma R2-bearing T cells. Furthermore, it can indirectly prevent further T-cell activation by creating a microenvironment that influences the function of antigen-presenting cells (APCs) as a result of IFN gamma-induced inducible nitric oxide synthase (iNOS), indoleamine-2,3-dioxygenase (IDO) and heme oxygenase (HO)-1 expression.

引用

页码：183 / 187

页数：5

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