A coactivator code for transcription

被引：46

作者：

Gamble, MJ ^{[1
]}

Freedman, LP ^{[1
]}

机构：

[1] Cornell Univ, Weill Grad Sch Med Sci, Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 04期

关键词：

D O I：

10.1016/S0968-0004(02)02076-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study of the covalent modifications of the N-terminal tails of histones and their effects on chromatin structure and function, known as the histone code, is proceeding at a rapid pace. Recent work by several groups suggests that coactivators, such as p300/CBP are also controlled by an array of various covalent modifications. This suggests the existence of a 'coactivator code' for p300/CBP and other seemingly promiscuous coregulators. Such a code could have wide-reaching implications for conferring specificity to general, ubiquitous transcriptional regulatory factors.

引用

收藏

页码：165 / 167

页数：3

相关论文

共 20 条

[1] Methylation at arginine 17 of histone H3 is linked to gene activation [J].

Bauer, UM ;

Daujat, S ;

Nielsen, SJ ;

Nightingale, K ;

Kouzarides, T .

EMBO REPORTS, 2002, 3 (01) :39-44

[2] Regulation of transcription by a protein methyltransferase [J].

Chen, DG ;

Ma, H ;

Hong, H ;

Koh, SS ;

Huang, SM ;

Schurter, BT ;

Aswad, DW ;

Stallcup, MR .

SCIENCE, 1999, 284 (5423) :2174-2177

[3] Synergistic, p160 coactivator-dependent enhancement of estrogen receptor function by CARM1 and p300 [J].

Chen, DG ;

Huang, SM ;

Stallcup, MR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (52) :40810-40816

[4] Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase [J].

Chen, HW ;

Lin, RJ ;

Xie, W ;

Wilpitz, D ;

Evans, RM .

CELL, 1999, 98 (05) :675-686

[5] Signaling to chromatin through histone modifications [J].

Cheung, P ;

Allis, CD ;

Sassone-Corsi, P .

CELL, 2000, 103 (02) :263-271

[6] Mechanisms for ATP-dependend chromatin remodelling [J].

Flaus, A ;

Owen-Hughes, T .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (02) :148-154

[7]

Goodman RH, 2000, GENE DEV, V14, P1553

[8] Translating the histone code [J].

Jenuwein, T ;

Allis, CD .

SCIENCE, 2001, 293 (5532) :1074-1080

[9] SPY-TEC: An efficient indexing method for similarity search in high-dimensional data spaces [J].

Lee, DH ;

Kim, HJ .

DATA & KNOWLEDGE ENGINEERING, 2000, 34 (01) :77-97

[10] Nuclear receptor cofactors as chromatin remodelers [J].

Lemon, BD ;

Freedman, LP .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1999, 9 (05) :499-504