Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C

被引：30

作者：

Booth, David ^{[1
]}

George, Jacob ^{[2
,3
]}

机构：

[1] Univ Sydney, Inst Immunol & Allergy Res, Westmead Millennium Inst, Sydney, NSW 2006, Australia

[2] Univ Sydney, Storr Liver Unit, Westmead Millennium Inst, Sydney, NSW 2006, Australia

[3] Univ Sydney, Westmead Hosp, Sydney, NSW 2006, Australia

来源：

NATURE GENETICS | 2013年 / 45卷 / 02期

关键词：

GENETIC-VARIATION; IL28B GENOTYPE; VIRAL KINETICS; EXPRESSION; THERAPY;

D O I：

10.1038/ng.2537

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Attempts to elucidate the mechanism underpinning the genetic association between IFNL3, previously called IL28B, and clearance of hepatitis C virus have, by and large, been unsuccessful. A study in this issue suggests that a new gene, IFNL4, may be responsible.

引用

页码：119 / 120

页数：2

共 14 条

[1] Effect of IL28B Genotype on Early Viral Kinetics During Interferon-Free Treatment of Patients With Chronic Hepatitis C [J].

Chu, Tom W. ;

Kulkarni, Rohit ;

Gane, Edward J. ;

Roberts, Stuart K. ;

Stedman, Catherine ;

Angus, Peter W. ;

Ritchie, Brett ;

Lu, Xiao-Yu ;

Ipe, David ;

Lopatin, Uri ;

Germer, Soren ;

Iglesias, Victor A. ;

Elston, Robert ;

Smith, Patrick F. ;

Shulman, Nancy S. .

GASTROENTEROLOGY, 2012, 142 (04) :790-795

[2] Interferon-Induced Gene Expression Is a Stronger Predictor of Treatment Response Than IL28B Genotype in Patients With Hepatitis C [J].

Dill, Michael T. ;

Duong, Francois H. T. ;

Vogt, Julia E. ;

Bibert, Stephanie ;

Bochud, Pierre-Yves ;

Terracciano, Luigi ;

Papassotiropoulos, Andreas ;

Roth, Volker ;

Heim, Markus H. .

GASTROENTEROLOGY, 2011, 140 (03) :1021-U471

[3] Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance [J].

Ge, Dongliang ;

Fellay, Jacques ;

Thompson, Alexander J. ;

Simon, Jason S. ;

Shianna, Kevin V. ;

Urban, Thomas J. ;

Heinzen, Erin L. ;

Qiu, Ping ;

Bertelsen, Arthur H. ;

Muir, Andrew J. ;

Sulkowski, Mark ;

McHutchison, John G. ;

Goldstein, David B. .

NATURE, 2009, 461 (7262) :399-401

[4] Hepatic ISG Expression Is Associated With Genetic Variation in Interleukin 28B and the Outcome of IFN Therapy for Chronic Hepatitis C [J].

Honda, Masao ;

Sakai, Akito ;

Yamashita, Tatsuya ;

Nakamoto, Yasunari ;

Mizukoshi, Eishiro ;

Sakai, Yoshio ;

Yamashita, Taro ;

Nakamura, Mikiko ;

Shirasaki, Takayoshi ;

Horimoto, Katsuhisa ;

Tanaka, Yasuhito ;

Tokunaga, Katsushi ;

Mizokami, Masashi ;

Kaneko, Shuichi .

GASTROENTEROLOGY, 2010, 139 (02) :499-509

[5]

Jacobson I.M., 2011, J HEPATOL S1, V54

[6] Dysregulation of innate immunity in hepatitis C virus genotype 1 IL28B-unfavorable genotype patients: Impaired viral kinetics and therapeutic response [J].

Naggie, Susanna ;

Osinusi, Anu ;

Katsounas, Antonios ;

Lempicki, Richard ;

Herrmann, Eva ;

Thompson, Alexander J. ;

Clark, Paul J. ;

Patel, Keyur ;

Muir, Andrew J. ;

McHutchison, John G. ;

Schlaak, Joerg F. ;

Trippler, Martin ;

Shivakumar, Bhavana ;

Masur, Henry ;

Polis, Michael A. ;

Kottilil, Shyam .

HEPATOLOGY, 2012, 56 (02) :444-454

[7]

Poordad F., 2011, HEPATOLOGY S1, V54

[8] A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus [J].

Prokunina-Olsson, Ludmila ;

Muchmore, Brian ;

Tang, Wei ;

Pfeiffer, Ruth M. ;

Park, Heiyoung ;

Dickensheets, Harold ;

Hergott, Dianna ;

Porter-Gill, Patricia ;

Mumy, Adam ;

Kohaar, Indu ;

Chen, Sabrina ;

Brand, Nathan ;

Tarway, McAnthony ;

Liu, Luyang ;

Sheikh, Faruk ;

Astemborski, Jacquie ;

Bonkovsky, Herbert L. ;

Edlin, Brian R. ;

Howell, Charles D. ;

Morgan, Timothy R. ;

Thomas, David L. ;

Rehermann, Barbara ;

Donnelly, Raymond P. ;

O'Brien, Thomas R. .

NATURE GENETICS, 2013, 45 (02) :164-171

[9] Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study [J].

Rauch, Andri ;

Kutalik, Zoltan ;

Descombes, Patrick ;

Cai, Tao ;

Di Iulio, Julia ;

Mueller, Tobias ;

Bochud, Murielle ;

Battegay, Manuel ;

Bernasconi, Enos ;

Borovicka, Jan ;

Colombo, Sara ;

Cerny, Andreas ;

Dufour, Jean-Francois ;

Furrer, Hansjakob ;

Guenthard, Huldrych F. ;

Heim, Markus ;

Hirschel, Bernard ;

Malinverni, Raffaele ;

Moradpour, Darius ;

Muellhaupt, Beat ;

Witteck, Andrea ;

Beckmann, Jacques S. ;

Berg, Thomas ;

Bergmann, Sven ;

Negro, Francesco ;

Telenti, Amalio ;

Bochud, Pierre-Yves .

GASTROENTEROLOGY, 2010, 138 (04) :1338-U173

[10] Identification of improved IL28B SNPs and haplotypes for prediction of drug response in treatment of hepatitis C using massively parallel sequencing in a cross-sectional European cohort [J].

Smith, Katherine R. ;

Suppiah, Vijayaprakash ;

O'Connor, Kate ;

Berg, Thomas ;

Weltman, Martin ;

Abate, Maria Lorena ;

Spengler, Ulrich ;

Bassendine, Margaret ;

Matthews, Gail ;

Irving, William L. ;

Powell, Elizabeth ;

Riordan, Stephen ;

Ahlenstiel, Golo ;

Stewart, Graeme J. ;

Bahlo, Melanie ;

George, Jacob ;

Booth, David R. .

GENOME MEDICINE, 2011, 3

← 1 2 →