Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase

被引：280

作者：

Bi, L ^{[1
]}

Okabe, I ^{[1
]}

Bernard, DJ ^{[1
]}

Nussbaum, RL ^{[1
]}

机构：

[1] NHGRI, Genet Dis Res Branch, NIH, Bethesda, MD 20892 USA

来源：

MAMMALIAN GENOME | 2002年 / 13卷 / 03期

关键词：

D O I：

10.1007/s00335-001-2123-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

[No abstract available]

引用

收藏

页码：169 / 172

页数：4

相关论文

共 22 条

[1]

WORTMANNIN IS A POTENT PHOSPHATIDYLINOSITOL 3-KINASE INHIBITOR - THE ROLE OF PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE IN NEUTROPHIL RESPONSES [J].

ARCARO, A ;

WYMANN, MP .

BIOCHEMICAL JOURNAL, 1993, 296 :297-301

[2]

A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human colon carcinoma cells [J].

Bénistant, C ;

Chapuis, H ;

Roche, S .

ONCOGENE, 2000, 19 (44) :5083-5090

[3]

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase [J].

Bi, L ;

Okabe, I ;

Bernard, DJ ;

Wynshaw-Boris, A ;

Nussbaum, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) :10963-10968

[4]

Phosphatidylinositol-3-OH kinases are Rab5 effectors [J].

Christoforidis, S ;

Miaczynska, M ;

Ashman, K ;

Wilm, M ;

Zhao, LY ;

Yip, SC ;

Waterfield, MD ;

Backer, JM ;

Zerial, M .

NATURE CELL BIOLOGY, 1999, 1 (04) :249-252

[5]

Fibroblast growth factor receptor 3 is a negative regulator of bone growth [J].

Deng, CX ;

WynshawBoris, A ;

Zhou, F ;

Kuo, A ;

Leder, P .

CELL, 1996, 84 (06) :911-921

[6]

Phosphoinositide kinases [J].

Fruman, DA ;

Meyers, RE ;

Cantley, LC .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :481-507

[7]

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α [J].

Fruman, DA ;

Snapper, SB ;

Yballe, CM ;

Davidson, L ;

Yu, JY ;

Alt, FW ;

Cantley, LC .

SCIENCE, 1999, 283 (5400) :393-397

[8]

ETHANOL PRECIPITATION OF DNA WITH LINEAR POLYACRYLAMIDE AS CARRIER [J].

GAILLARD, C ;

STRAUSS, F .

NUCLEIC ACIDS RESEARCH, 1990, 18 (02) :378-378

[9]

Specific requirement for the p85-p110α phosphatidylinositol 3-kinase during epidermal growth factor-stimulated actin nucleation in breast cancer cells [J].

Hill, K ;

Welti, S ;

Yu, JH ;

Murray, JT ;

Yip, SC ;

Condeelis, JS ;

Segall, JE ;

Backer, JM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (06) :3741-3744

[10]

Hooshmand-Rad R, 2000, J CELL SCI, V113, P207