Pyralomicins, novel antibiotics from Microtetraspora spiralis .3. Biosynthesis of pyralomicin 1a

被引：24

作者：

Kawamura, N

Sawa, R

Takahashi, Y

Sawa, T

Naganawa, H

Takeuchi, T

机构：

[1] Institute of Microbial Chemistry, Shinagawa-ku, Tokyo 141

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 07期

关键词：

D O I：

10.7164/antibiotics.49.657

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The biosynthesis of pyralomicin la (1) was studied by feeding of C-13 and N-15 labeled compounds to the culture of Microtetraspora spiralis MI178-34F18. The result indicated that the benzopyranopyrrole unit of 1 was derived from two units of acetate, one unit of propionate and one unit of proline, and that the cyclitol unit of 1 was derived from glucose metabolites. And 4'-O-CH3 was derived from the S-CH3 group of methionine.

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页码：657 / 660

页数：4

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