Regulation of the human immune response during tuberculosis

被引：40

作者：

Ellner, JJ

机构：

[1] Department of Medicine, University Hospitals of Cleveland, Cleveland, OH

[2] Department of Medicine, University Hospitals of Cleveland, Cleveland, OH 44106

来源：

JOURNAL OF LABORATORY AND CLINICAL MEDICINE | 1997年 / 130卷 / 05期

关键词：

D O I：

10.1016/S0022-2143(97)90123-2

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

pulmonary tuberculosis is characterized by depression of purified protein derivative-stimulated (PPD-stimulated) blastogenesis in peripheral blood mononuclear cells (PBMCs) as well as decreased production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma). Circulating T cells and monocytes (MNs) are nonspecifically activated in situ. PPD directly stimulates the primed MNs from patients with tuberculosis (TB) to overproduce a panoply of cytokines including transforming growth factor-beta (TGF-beta) and IL-10, which serve to depress PPD-stimulated blastogenesis and cytokine expression. Cross-modulation by these immunosuppressive MN products is superimposed on a primary T cell abnormality that persists for at least 12 months after the diagnosis of TB and involves apoptotic mechanisms.

引用

页码：469 / 475

页数：7

共 17 条

[1] Induction of monocyte expression of tumor necrosis factor alpha by the 30-kD alpha antigen of Mycobacterium tuberculosis and synergism with fibronectin [J].