A human genome map of comparative anchor tagged sequences

被引:11
作者
Chen, ZQ
Lautenberger, JA
Lyons, LA
McKenzie, L
O'Brien, SJ [1 ]
机构
[1] NCI, Lab Genom Divers, Frederick, MD USA
[2] NCI, Intramural Res Support Program, SAIC Frederick, Frederick, MD 21702 USA
关键词
D O I
10.1093/jhered/90.4.477
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Effective comparative mapping inference utilizing developing gene maps of animal species requires the inclusion of anchored reference loci that are homologous to genes mapped in the more "gene-dense" mouse and human maps, Nominated anchor loci, termed comparative anchor tagged sequences (CATS), have been ordered in the mouse linkage map, but due to the dearth of common polymorphisms among human coding genes have not been well represented in human linkage maps. We present here an ordered framework map of 314 comparative anchor markers in humans based on mapping analysis in the Genebridge 4 panel of radiation hybrid cell lines, plus empirically optimized CATS PCR primers which detect these markers. The ordering of these homologous gene markers in human and mouse maps provides a framework for comparative gene mapping of representative mammalian species.
引用
收藏
页码:477 / 484
页数:8
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