Expression of the liver X receptor α and β in embryonic and adult mice

被引：70

作者：

Annicotte, JS

Schoonjans, K

Auwerx, J

机构：

[1] ULP, INSERM, CNRS, IGBMC, F-67404 Illkirch Graffenstaden, France

[2] Inst Clin Souris, Illkirch Graffenstaden, France

来源：

ANATOMICAL RECORD PART A-DISCOVERIES IN MOLECULAR CELLULAR AND EVOLUTIONARY BIOLOGY | 2004年 / 277A卷 / 02期

关键词：

brain; development; embryogenesis; liver X receptor; nuclear receptors;

D O I：

10.1002/ar.a.20015

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

We characterized the expression pattern of the nuclear receptors liver X receptor (LXR) alpha and beta during mouse embryonic development and in adulthood by in situ hybridization experiments. LXRalpha and LXRbeta are detected in the liver starting at 11.5 days postcoitum. Later, LXRalpha expression remains high in organs involved in lipid homeostasis, such as liver, intestine, and brown adipose tissue, whereas LXRbeta is more ubiquitously expressed and enriched in tissues of neuronal and endocrine origin. (C) 2004 Wiley-Liss, Inc.

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页码：312 / 316

页数：5

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