Presenilin 1 protein directly interacts with Bcl-2

被引：59

作者：

Alberici, A

Moratto, D

Benussi, L

Gasparini, L

Ghidoni, R

Gatta, LB

Finazzi, D

Frison, GB

Trabucchi, M

Growdon, JH

Nitsch, RM

Binetti, G

机构：

[1] Ist Ricovero & Cura Carattere Sci, Ctr S Giovanni Dio, Neurobiol Lab, Alzheimers Dis Unit, I-25123 Brescia, Italy

[2] Univ Brescia, Sch Med, Inst Chem, I-25123 Brescia, Italy

[3] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00154 Rome, Italy

[4] Univ Zurich, Dept Psychiat Res, CH-8091 Zurich, Switzerland

[5] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02114 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1999年 / 274卷 / 43期

关键词：

D O I：

10.1074/jbc.274.43.30764

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Presenilin proteins are involved in familial Alzheimer's disease, a neurodegenerative disorder characterized by massive death of neurons. We describe a direct interaction between presenilin 1 (PS1) and Bcl-2, a key factor in the regulation of apoptosis, by yeast two-hybrid interaction system, by co-immunoprecipitation, and by cross-linking experiments. Our data show that PS1 and Bcl-2 assemble into a macromolecular complex, and that they are released from this complex in response to an apoptotic: stimulus induced by staurosporine. The results support the idea of cross-talk between these two proteins during apoptosis.

引用

页码：30764 / 30769

页数：6

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