Endocrine treatment of advanced breast cancer

被引:6
作者
Dowsett, M
机构
[1] Royal Marsden Hospital, London SW3 6JJ, Fulham Road
关键词
D O I
10.3109/02841869609083973
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Endocrine treatment is the preferred first-line therapy for advanced breast cancer because of its good tolerability, There are several groups of agents which differ in their mode of action but almost all in some way reduce stimulation by oestrogen, Over recent years, there has been a substantial increase in the number of medical agents in clinical trial, New antioestrogens with reduced or no agonist activity, and potent, more specific, aromatase inhibitors are now reaching the clinic, In most cases, the clinical effectiveness of these agents remains to be fully established and their optimal therapeutic application is yet to be determined.
引用
收藏
页码:68 / 72
页数:5
相关论文
共 34 条
  • [1] ABE O, 1992, LANCET, V339, P71
  • [2] Beatson GT., 1896, LANCET, V148, P104, DOI DOI 10.1016/S0140-6736(01)72307-0
  • [3] MEDROXYPROGESTERONE ACETATE THERAPY IN ADVANCED BREAST-CANCER - THE PREDICTIVE VALUE OF ANDROGEN RECEPTOR EXPRESSION
    BIRRELL, SN
    RODER, DM
    HORSFALL, DJ
    BENTEL, JM
    TILLEY, WD
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (07) : 1572 - 1577
  • [4] CARRION RP, ANN ONCOLOGY S7, V5, P19
  • [5] CHANDER SK, 1991, CANCER RES, V51, P5851
  • [6] COOMBES RC, 1992, EUR J CANCER, V28A, P1941
  • [7] DEFRIEND DJ, 1994, CANCER RES, V54, P408
  • [8] AROMATIZATION INHIBITION ALONE OR IN COMBINATION WITH GNRH AGONISTS FOR THE TREATMENT OF PREMENOPAUSAL BREAST-CANCER PATIENTS
    DOWSETT, M
    STEIN, RC
    COOMBES, RC
    [J]. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 43 (1-3) : 155 - 159
  • [9] EFFECTS OF THE PURE ANTIESTROGEN ICI-182780 ON ESTROGEN-RECEPTORS, PROGESTERONE RECEPTORS AND KI67 ANTIGEN IN HUMAN ENDOMETRIUM IN-VIVO
    DOWSETT, M
    HOWELL, R
    SALTER, J
    THOMAS, NM
    THOMAS, EJ
    [J]. HUMAN REPRODUCTION, 1995, 10 (02) : 262 - 267
  • [10] Dowsett M, 1995, CLIN CANCER RES, V1, P1511