New sesquiterpene lactones from the Portuguese liverwort Targionia lorbeeriana

被引：40

作者：

Neves, M

Morais, R

Gafner, S

Stoeckli-Evans, H

Hostettmann, K

机构：

[1] UCP, Escola Super Biotecnol, P-4200 Porto, Portugal

[2] Univ Lausanne, Inst Pharmacognosie & Phytochim, CH-1015 Lausanne, Switzerland

[3] Univ Neuchatel, Inst Chim, CH-2000 Neuchatel, Switzerland

来源：

PHYTOCHEMISTRY | 1999年 / 50卷 / 06期

关键词：

liverwort; T-lorbeeriana; targionaceae; phytochemistry; bioassay; terpenoids; sesquiterpene lactones;

D O I：

10.1016/S0031-9422(98)00648-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new sesquiterpene lactones (acetyltrifloculoside, 8.15-acetylsalonitenolide and 8-acelylsalonitenolide) and two known sesquiterpene lactones were isolated from a dichloromethane extract of the Portuguese liverwort Targionia lorbeeriana. Their structures were established by spectroscopic methods (EI and D/CI mass spectroscopy. H-1 and C-13 NMR) and that of acetyltrifloculoside was confirmed by X-ray crystallography. The three isolated guaianolide sesquiterpene lactones presented antifungal activity against Cladosporium cucumerinum and larvicidal activity against Aedes aegypti. Only one of the isolated lactones presented activity against Candida albicans. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：967 / 972

页数：6

共 24 条

[1] TERPENOIDS FROM THE FRENCH LIVERWORT TARGIONIA-HYPOPHYLLA [J].