Tourette syndrome: Prediction of phenotypic variation in monozygotic twins by caudate nucleus D2 receptor binding

被引：183

作者：

Wolf, SS ^{[1
]}

Jones, DW ^{[1
]}

Knable, MB ^{[1
]}

Gorey, JG ^{[1
]}

Lee, KS ^{[1
]}

Hyde, TM ^{[1
]}

Coppola, R ^{[1
]}

Weinberger, DR ^{[1
]}

机构：

[1] NIMH,CLIN BRAIN DISORDERS BRANCH,INTRAMURAL RES PROGRAM,NIH,NEUROSCI CTR ST ELIZABETHS,WASHINGTON,DC 20032

来源：

SCIENCE | 1996年 / 273卷 / 5279期

关键词：

D O I：

10.1126/science.273.5279.1225

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tourette syndrome, a chronic tic disorder with autosomal dominant inheritance, exhibits considerable phenotypic variability even within monozygotic twin pairs. The origins of this variability remain unclear. Recent findings have implicated the caudate nucleus as a locus of pathology, and pharmacological evidence supports dopaminergic involvement. Within monozygotic twins discordant for Tourette syndrome severity, differences in D2 dopamine receptor binding in the head of the caudate nucleus predicted differences in phenotypic severity (r = 0.99); this relation was not observed in putamen. These data may link Tourette syndrome with a spectrum of neuropsychiatric disorders that involve associative striatal circuitry.

引用

页码：1225 / 1227

页数：3

共 31 条

[1] PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].