Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein

被引：41

作者：

Zhang, PL ^{[1
]}

Izrael, M ^{[1
]}

Ainbinder, E ^{[1
]}

Ben-Simchon, L ^{[1
]}

Chebath, J ^{[1
]}

Revel, M ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2006年 / 31卷 / 03期

关键词：

D O I：

10.1016/j.mcn.2005.10.014

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurosphere cells (NSc) derived from embryonic stern cells have characteristics of neural stern cells and can differentiate into oligoden-drocyte precursors. Culture of NSc with IL6RIL6 chimera (soluble interlenkin-6 receptor fused to interieukin-6) enhances their differentiation into oligodendrocytes with longer and more numerous branches and with peripheral accumulation of myelin basic protein (MBP) in myelin membranes indicating maturation. Gene expression profiling reveals that one of the proteins strongly induced by IL6RIL6 is a regulator of microtubule dynamics, stathmin-like 2 (SCG10/Stmn2), and gene silencing shows that Stmn2 plays an important role in the development of the mature oligodendrocyte morphology. IL61RIL6 acts as an effective stimulator of the myelinating function of ES cell-derived oligodendrocyte precursors, as observed upon transplantation of the IL6RIL6- pretreated cells into brain slices of MBP-deficient shiverer mice. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：387 / 398

页数：12

共 60 条

[1] CNS MYELINOGENESIS IN-VITRO - TIME-COURSE AND PATTERN OF RAT OLIGODENDROCYTE DEVELOPMENT [J].

ASOU, H ;

HAMADA, K ;

MIYAZAKI, T ;

SAKOTA, T ;

HAYASHI, K ;

TAKEDA, Y ;

MARRET, S ;

DELPECH, B ;

ITOH, K ;

UYEMURA, K .

JOURNAL OF NEUROSCIENCE RESEARCH, 1995, 40 (04) :519-534

[2] Ciliary neurotrophic factor enhances the rate of oligodendrocyte generation [J].

Barres, BA ;

Burne, JF ;

Holtmann, B ;

Thoenen, H ;

Sendtner, M ;

Raff, MC .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1996, 8 (2-3) :146-156

[3] A CRUCIAL ROLE FOR NEUROTROPHIN-3 IN OLIGODENDROCYTE DEVELOPMENT [J].

BARRES, BA ;

RAFF, MC ;

GAESE, F ;

BARTKE, I ;

DECHANT, G ;

BARDE, YA .

NATURE, 1994, 367 (6461) :371-375

[4]

BARRES BA, 1993, DEVELOPMENT, V118, P283

[5]

BARRES BA, 1994, DEVELOPMENT, V120, P1097

[6] COOPERATION BETWEEN 2 GROWTH-FACTORS PROMOTES EXTENDED SELF-RENEWAL AND INHIBITS DIFFERENTIATION OF OLIGODENDROCYTE TYPE-2 ASTROCYTE (O-2A) PROGENITOR CELLS [J].

BOGLER, O ;

WREN, D ;

BARNETT, SC ;

LAND, H ;

NOBLE, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) :6368-6372

[7] Embryonic stem cell-derived glial precursors:: A source of myelinating transplants [J].

Brüstle, O ;

Jones, KN ;

Learish, RD ;

Karram, K ;

Choudhary, K ;

Wiestler, OD ;

Duncan, ID ;

McKay, RDG .

SCIENCE, 1999, 285 (5428) :754-756

[8]

CAMPAGNONI AT, 1991, ANN NY ACAD SCI, V633, P178

[9] Stem cell repair of central nervous system injury [J].

Cao, QL ;

Benton, RL ;

Whittemore, SR .

JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 68 (05) :501-510

[10]

Carson JH, 1997, CELL MOTIL CYTOSKEL, V38, P318, DOI 10.1002/(SICI)1097-0169(1997)38:4<318::AID-CM2>3.0.CO

← 1 2 3 4 5 6 →