Association and linkage of juvenile MS with HLA-DR2(15) in Russians

被引：40

作者：

Boiko, AN

Gusev, EI

Sudomoina, MA

Alekseenkov, AD

Kulakova, OG

Bikova, OV

Maslova, OI

Guseva, MR

Boiko, SY

Guseva, ME

Favorova, OO

机构：

[1] Russian State Med Univ, Dept Mol Biol & Med Biotechnol, Moscow 121552, Russia

[2] Russian State Med Univ, Dept Neurol & Neurosurg, Moscow 121552, Russia

[3] Russian Acad Med Sci, Inst Pediat, Psychoneurol Dept, Moscow, Russia

来源：

NEUROLOGY | 2002年 / 58卷 / 04期

关键词：

D O I：

10.1212/WNL.58.4.658

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this study was to determine the role of the HLA-DRB1 gene [6p21] in susceptibility to juvenile MS (JMS) (age at onset less than or equal to15 years) of children of Russian descent. Association of DR2(15) with JMS has been found by the comparison of patients with JMS with both unrelated and affected family-based healthy controls. The linkage of DR2(15) with JMS was shown by transmission disequilibrium test. There were no significant differences in the frequencies of DRB1 alleles and genotypes between 56 patients with JMS and 234 patients with MS with age at onset greater than or equal to16 years.

引用

页码：658 / 660

页数：3

共 11 条

[1] RISK OF MULTIPLE SCLEROSIS RELATED TO AGE AT IMMIGRATION TO ISRAEL [J].