Regulation of ion channels by integrins

被引:57
作者
Davis, MJ [1 ]
Wu, X
Nurkiewicz, TR
Kawasaki, J
Gui, PC
Hill, MA
Wilson, E
机构
[1] Texas A&M Univ Syst, Hlth Sci Ctr, Cardiovasc Res Inst, Dept Med Physiol, College Stn, TX 77843 USA
[2] RMIT Univ, Dept Human Biol, Bundoora, Vic, Australia
关键词
receptor tyrosine kinase; nonreceptor tyrosine kinase; integrins; cytoskeleton; focal adhesion; growth factor receptors; scaffolding proteins; Src; FAK; AKAP; SH3;
D O I
10.1385/CBB:36:1:41
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Ion channels are regulated by protein phosphorylation and dephosphorylation of serine, threonine, and tyrosine residues. Evidence for regulation of channels by tyrosine phosphorylation comes primarily from investigations of the effects of growth factors, which act through receptor tyrosine kinases. The purpose of the present work is to summarize evidence for the regulation of ion channels by integrins, through their downstream, nonreceptor tyrosine kinases. We review both direct and indirect evidence for this regulation, with particular emphasis on Ca2+-activated K+ and voltage-gated Ca2+ channels. We then discuss the critical roles that cytoskeletal, focal-adhesion, and channel-associated scaffolding proteins may play in localizing nonreceptor tyrosine kinases to the vicinity of ion channels. We conclude by speculating on the physiological significance of these regulatory pathways.
引用
收藏
页码:41 / 66
页数:26
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