Intraocular levels of methotrexate after intravenous administration

被引：44

作者：

deSmet, MD

StarkVancs, V

Kohler, DR

Smith, J

Wittes, R

Nussenblatt, RB

机构：

[1] NEI,IMMUNOL LAB,NIH,BETHESDA,MD 20892

[2] NCI,DIV CANC TREATMENT,NIH,BETHESDA,MD

[3] NIH,DEPT PHARM,WARREN G MAGNUSON CLIN CTR,BETHESDA,MD

来源：

AMERICAN JOURNAL OF OPHTHALMOLOGY | 1996年 / 121卷 / 04期

关键词：

D O I：

10.1016/S0002-9394(14)70444-1

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

PURPOSE: To determine if adequate intraocular levels of methotrexate are achieved after intravenous administration. METHODS: After intravenous administration, methotrexate levels were determined in the serum, the anterior chamber, and the cerebrospinal fluids of a patient with recurrent ocular lymphoma. A fluorescence polarization immunoassay was used to make the determinations. RESULTS: At seven hours into a 24-hour intravenous infusion, methotrexate was at cytotoxic level in all samples. At 74 hours, cytotoxic levels were present only in the aqueous humor. CONCLUSION: Sustained cytotoxic ocular methotrexate levels are achievable after systemic administration.

引用

页码：442 / 444

页数：3

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