The oxetane conformational lock of paclitaxel: Structural analysis of D-secopaclitaxel

被引：28

作者：

Boge, TC ^{[1
]}

Hepperle, M ^{[1
]}

Vander Velde, DG ^{[1
]}

Gunn, CW ^{[1
]}

Grunewald, GL ^{[1
]}

Georg, GI ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(99)00521-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analysis of the H-1 NMR data of paclitaxel in comparison with its oxetane ring-opened analogue D-secopaclitaxel suggests that the oxetane moiety (D-ring) of paclitaxel serves as a conformational lock for the diterpene moiety and the C13 side chain. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：3041 / 3046

页数：6

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