Identification strategy of RHCE gene variants at the National Blood group reference Laboratory impact on transfusion safety

被引：4

作者：

Ansart-Pirenne, H

机构：

[1] Inst Natl Transfus Sanguine, CNRGS, F-75522 Paris 11, France

[2] INSERM, U665, F-75015 Paris, France

来源：

TRANSFUSION CLINIQUE ET BIOLOGIQUE | 2006年 / 13卷 / 1-2期

关键词：

blood groups; Rh; RHCE gene; polymorphism; transfusion; safety;

D O I：

10.1016/j.tracli.2006.02.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The RH blood group is the most polymorphic and immunogenic blood group system. The RH locus is composed of 2 highly homologous genes: the RHD gene encoding the D polypeptide; and the RHCE gene, encoding C or c together with either E or e polypeptides. Numerous variants exist for both RHD and RHCE genes. Among them we were interested in the serological and molecular definition of numerous pre-published RHCE variants encountered in different populations. The identification of these variants is crucial to ensure the transfusion safety for patients expressing these variants. Here we propose a procedure to identify some of them and discuss the adequate transfusion strategy. This procedure has enable Lis to identify new variants to be presented at the symposium. (c) 2006 Elsevier SAS. Tous droits reserves.

引用

页码：13 / 18

页数：6

共 34 条

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