Prevention of human cancer by modulation of chronic inflammatory processes

被引:119
作者
Ohshima, H [1 ]
Tazawa, H [1 ]
Sylla, BS [1 ]
Sawa, T [1 ]
机构
[1] Int Agcy Res Canc, F-69372 Lyon, France
关键词
cancer; inflammation; reactive oxygen species; reactive nitrogen species; iNOS; COX-2; NF-kappa B;
D O I
10.1016/j.mrfmmm.2005.03.030
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Chronic inflammation induced by biological, chemical and physical factors has been associated with increased risk of human cancer at various sites. Inflammation facilitates the initiation of normal cells and their growth and progression to malignancy through production of pro-inflammatory cytokines and diverse reactive oxygen and nitrogen species. These also activate signaling molecules involved in inflammation and carcinogenesis such as nuclear transcription factor (NF-kappa B), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Several chemopreventive agents act through inhibition of signaling pathways (e.g. NF-kappa B), inhibition of oxidant-generating enzymes (e.g. NOS) and mediators of inflammation (c,g, COX-2), scavenging reactive oxygen and nitrogen species, and modulation of xenobiotic-metabolizing enzymes (especially phase 11 enzyme induction). Some anti-inflammatory drugs have been tested in clinical trials to prevent human cancer at several sites, Better understanding of the molecular mechanisms by which chronic inflammation increases cancer risk will lead to further development of new strategies for cancer prevention at many sites. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:110 / 122
页数:13
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