Synthesis of 3-substituted 4-aroylisoquinolines via Pd-catalyzed carbonylative cyclization of o-(1-alkynyl)benzaldimines

被引：53

作者：

Dai, GX ^{[1
]}

Larock, RC ^{[1
]}

机构：

[1] Iowa State Univ Sci & Technol, Dept Chem, Ames, IA 50011 USA

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 02期

关键词：

D O I：

10.1021/ol010230y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] o-(1-Alkynyl)benzaldimines react with aryl iodides and 1 atm of CO in the presence of tri-n-butylamine and a Pd(PPh3)(4) catalyst to afford good yields of 3-substituted 4-aroylisoquinolines by acylpalladation of the carbon-carbon triple bond and cyclization.

引用

页码：193 / 196

页数：4

共 12 条

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