The combined effect of augmentation index and carotid intima-media thickness on cardiovascular risk in young and middle-aged men without cardiovascular disease

被引：27

作者：

Stamatelopoulos, KS ^{[1
]}

Kalpakos, D ^{[1
]}

Protogerou, AD ^{[1
]}

Papamichael, CM ^{[1
]}

Ikonomidis, I ^{[1
]}

Tsitsirikos, M ^{[1
]}

Revela, I ^{[1
]}

Papaioannou, TG ^{[1
]}

Lekakis, JP ^{[1
]}

机构：

[1] Alexandra Univ Hosp, Dept Clin Therapeut, Vasc Lab, Athens 16675, Greece

来源：

JOURNAL OF HUMAN HYPERTENSION | 2006年 / 20卷 / 04期

关键词：

cardiovascular risk; pulse wave analysis; IMT; Framingham risk score; primary prevention;

D O I：

10.1038/sj.jhh.1001978

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Carotid artery intima- media thickness ( IMT) has been used as a surrogate marker of atherosclerosis and is related to cardiovascular risk. Indices of arterial stiffness are also associated with cardiovascular risk and atherosclerosis. The aim of this study was to assess the prognostic value of the combination of surrogate markers of cardiovascular disease measured non- invasively in subjects without cardiovascular disease. In this cross- sectional study, 81 young and middle aged males ( 39.276.3 years) without evidence of overt cardiovascular disease or diabetes mellitus were enrolled. High-resolution B- mode ultrasonography and pulse wave analysis were used to measure carotid artery IMT and augmentation index ( AI), a measure of arterial stiffness. Framingham risk score ( FRS) was used as an estimate of the risk for development of cardiovascular disease. Regional differences were observed in the carotid arteries' IMT regarding their relationship with FRS: combined ( average from all sites) IMT and IMT in the carotid bulb ( CB), but not in the common ( CC) and internal carotid artery ( IC), and AI showed significant increases of FRS by their tertiles. However, subjects with both AI and IMT at any site in the highest tertile ( Al > 415%, CC > 0.65mm, CB > 0.8mm, IC > 0.65mm) had an increased FRS compared to subjects with one or none of these parameters in the highest tertile. In conclusion, young and middle- aged men without overt cardiovascular disease with both high IMT and AI are in high cardiovascular risk, as assessed by FRS. Epidemiological studies are needed to further validate this combination.

引用

页码：273 / 279

页数：7

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