In vivo animal models for studying brain metastasis: value and limitations

被引：77

作者：

Daphu, Inderjit ^{[1
]}

Sundstrom, Terje ^{[1
,2
,3
]}

Horn, Sindre ^{[1
]}

Huszthy, Peter C. ^{[1
]}

Niclou, Simone P. ^{[4
]}

Sakariassen, Per O. ^{[1
]}

Immervoll, Heike ^{[5
]}

Miletic, Hrvoje ^{[1
,5
]}

Bjerkvig, Rolf ^{[1
,4
]}

Thorsen, Frits ^{[1
]}

机构：

[1] Univ Bergen, Dept Biomed, NorLux Neurooncol Lab, N-5019 Bergen, Norway

[2] Univ Bergen, Dept Surg Sci, N-5019 Bergen, Norway

[3] Haukeland Hosp, Dept Neurosurg, N-5021 Bergen, Norway

[4] Ctr Rech Publ Sante, NorLux Neurooncol Lab, Luxembourg, Luxembourg

[5] Haukeland Hosp, Dept Pathol, N-5021 Bergen, Norway

来源：

CLINICAL & EXPERIMENTAL METASTASIS | 2013年 / 30卷 / 05期

关键词：

Brain metastasis; Animal models; Orthotopic; Ectopic; GEMMs; BREAST-CANCER CELLS; MURINE MELANOMA; LUNG-CANCER; NUDE-MICE; PLEURAL EFFUSION; GROWTH-FACTOR; MOUSE MODELS; EXPRESSION; CARCINOMA; LINES;

D O I：

10.1007/s10585-013-9566-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Brain metastasis is associated with a particular poor prognosis. Novel insight into the brain metastatic process is therefore warranted. Several preclinical models of brain tumor metastasis have been developed during the last 60 years, and they have in part revealed some of the mechanisms underlying the metastatic process. This review discusses mechanisms of brain metastasis with a key focus of the development of animal model systems. This includes the use of rodent, syngeneic brain metastasis models (spontaneous, chemically induced and genetically engineered models) and human xenotransplantation models (ectopic inoculation and orthotopic models). Current information indicates that none of these fully reflect tumor development seen in patients with metastatic disease. The various model systems used, however, have provided important insight into specific mechanisms of the metastatic process related to the brain. By combining the knowledge obtained from animal models, new important information on the molecular mechanisms behind metastasis will be obtained, leading to the future development of new therapeutic strategies.

引用

页码：695 / 710

页数：16

共 145 条

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