Ordered aggregation of big bodies with high asphericity in small spheres: a possible mechanism of the amyloid fibril formation

被引：27

作者：

Kinoshita, M ^{[1
]}

机构：

[1] Kyoto Univ, Inst Adv Energy, Uji, Kyoto 6110011, Japan

来源：

CHEMICAL PHYSICS LETTERS | 2004年 / 387卷 / 1-3期

关键词：

D O I：

10.1016/j.cplett.2004.01.112

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

This Letter provides an extension of the earlier study on the interaction entropically induced between big bodies with a variety of shapes, large solutes, immersed in small spheres forming the solvent. The pattern of the aggregation of big bodies, which is strongly dependent on the big-body shapes, is discussed. Cases where the big-body shapes are changeable are newly analyzed. A possible mechanism of the amyloid fibril formation, which could be categorized as an ordered arrangement of large solute molecules occurring to increase the solvent entropy, is described. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：54 / 60

页数：7

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