Genetic analysis of cadherin function in animal morphogenesis

被引：78

作者：

Tepass, U ^{[1
]}

机构：

[1] Univ Toronto, Dept Zool, Toronto, ON M5G 3G5, Canada

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0955-0674(99)00025-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cadherins are a superfamily of Ca2+-dependent adhesion molecules found in metazoans. Several classes of cadherins have been defined from which two - classic cadherins and Fat-like cadherins - have been studied by genetic approaches. Recent in vivo studies in Caenorhabditis elegans and Drosophila show that cadherins play an active role in a number of distinct morphogenetic processes, Classic cadherins function in epithelial polarization, epithelial sheet or tube fusion, cell migration, cell sorting, and axonal patterning. Fat-like cadherins are required for epithelial morphogenesis, proliferation control, and epithelial planar polarization.

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页码：540 / 548

页数：9

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