Plasma malondialdehyde and nitric oxide levels in age related macular degeneration

被引：57

作者：

Totan, Y

Çekiç, O

Borazan, M

Uz, E

Sögüt, S

Akyol, Ö

机构：

[1] Inonu Univ, Sch Med, Dept Ophthalmol, Turgut Ozal Med Ctr, Malatya, Turkey

[2] Inonu Univ, Sch Med, Dept Biochem, Turgut Ozal Med Ctr, Malatya, Turkey

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 2001年 / 85卷 / 12期

关键词：

D O I：

10.1136/bjo.85.12.1426

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Aims-To evaluate alteration of plasma malondialdehyde (MDA) and nitric oxide (NO) levels in patients with exudative age related macular degeneration (ARMD). Methods-Plasma. nitrite plus nitrate concentrations as an index of plasma NO levels and plasma MDA level as a marker of lipid peroxidation were measured in patients with exudative ARMD and age and sex matched healthy subjects. Results-Significantly higher MDA and lower NO levels were detected in plasma of patients with ARMD compared with their controls (p=0.01, p=0.001, respectively). Conclusion-The results may support involvement of oxidative damage and vascular theory in the pathogenesis of ARMD as part of the ageing process.

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页码：1426 / 1428

页数：3

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