Natural Killer Cell Memory

被引:300
作者
O'Sullivan, Timothy E. [1 ]
Sun, Joseph C. [1 ,2 ]
Lanier, Lewis L. [3 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY 10065 USA
[2] Weill Cornell Med Coll, Dept Immunol & Microbial Pathogenesis, New York, NY 10065 USA
[3] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA
关键词
HUMAN CYTOMEGALOVIRUS-INFECTION; HUMAN NK CELLS; SIMIAN IMMUNODEFICIENCY VIRUS; ANTIGEN-SPECIFIC MEMORY; EPSTEIN-BARR-VIRUS; CUTTING EDGE; T-CELLS; INFLUENZA INFECTION; VIRAL-INFECTION; RHESUS MACAQUES;
D O I
10.1016/j.immuni.2015.09.013
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of T and B cells. In this review, we discuss evidence of NK cell memory and the mechanisms involved in the generation and survival of these innate lymphocytes.
引用
收藏
页码:634 / 645
页数:12
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