Two antitumour ruthenium(III) complexes showing selectivity in their binding towards poly(dG)center dot poly(dC) and poly(dA)center dot poly(dT)

被引：18

作者：

Hartmann, M ^{[1
]}

Einhauser, TJ ^{[1
]}

Keppler, BK ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST ANORGAN CHEM,D-69120 HEIDELBERG,GERMANY

来源：

CHEMICAL COMMUNICATIONS | 1996年 / 15期

关键词：

D O I：

10.1039/cc9960001741

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The antitumour-active complexes trans-Him[(RuCl4)-Cl-III(im)(2)] (Him = imidazole) and trans-Hind[RumCl(4)(ind)(2)] (Hind = indazole) bind at a higher binding rate to poly(dG). poly(dC), compared to poly(dA). poly(dT); the covalent binding to the nucleobases requires a preceding aquation of the compounds, similar to cisplatin.

引用

页码：1741 / 1742

页数：2

共 17 条

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