Androgen receptor gene (CAG)n polymorphism in patients with polycystic ovary syndrome

被引:31
作者
Ferk, Polonca [1 ]
Perme, Maja Pohar [2 ]
Teran, Natasa [1 ]
Gersak, Ksenija [1 ]
机构
[1] Univ Med Ctr Ljubljana, Dept Obstet & Gynecol, Div Med Genet, SI-1000 Ljubljana, Slovenia
[2] Univ Ljubljana, Inst Biomed Informat, Ljubljana, Slovenia
关键词
D O I
10.1016/j.fertnstert.2007.07.1291
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
The aim of the present case-control study was to evaluate the incidence of the (CAG)(n) AR polymorphism in Slovene polycystic ovary syndrome (PCOS) patients. The polymorphism was not found to be a major risk factor for the presence of PCOS and for hyperandrogenemia in PCOS.
引用
收藏
页码:860 / 863
页数:4
相关论文
共 25 条
[11]  
Fujii Kenji, 2003, Leg Med (Tokyo), V5 Suppl 1, pS201, DOI 10.1016/S1344-6223(02)00111-6
[12]   The androgen receptor gene mutations database (ARDB): 2004 update [J].
Gottlieb, B ;
Beitel, LK ;
Wu, JH ;
Trifiro, M .
HUMAN MUTATION, 2004, 23 (06) :527-533
[13]   The androgen-receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome [J].
Hickey, T ;
Chandy, A ;
Norman, RJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (01) :161-165
[14]   What is polycystic ovarian syndrome? A proposal for a consensus on the definition and diagnosis of polycystic ovarian syndrome [J].
Homburg, R .
HUMAN REPRODUCTION, 2002, 17 (10) :2495-2499
[15]   Androgen receptor gene CAG repeat polymorphism in the development of ovarian hyperandrogenism [J].
Ibáñez, L ;
Ong, KK ;
Mongan, N ;
Jääskeläinen, J ;
Marcos, MV ;
Hughes, IA ;
De Zegher, F ;
Dunger, DB .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (07) :3333-3338
[16]   Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome [J].
Jääskeläinen, J ;
Korhonen, S ;
Voutilainen, R ;
Hippeläinen, M ;
Heinonen, S .
FERTILITY AND STERILITY, 2005, 83 (06) :1724-1728
[17]   Empirical estimation of free testosterone from testosterone and sex hormone-binding globulin immunoassays [J].
Ly, LP ;
Handelsman, DJ .
EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2005, 152 (03) :471-478
[18]   REDUCED TRANSCRIPTIONAL REGULATORY COMPETENCE OF THE ANDROGEN RECEPTOR IN X-LINKED SPINAL AND BULBAR MUSCULAR-ATROPHY (VOL 5, PG 184, 1993) [J].
MHATRE, AN ;
TRIFIRO, MA ;
KAUFMAN, M ;
KAZEMIESFARJANI, P ;
FIGLEWICZ, D ;
ROULEAU, G ;
PINSKY, L .
NATURE GENETICS, 1994, 6 (02) :214-214
[19]   Androgen receptor gene CAG trinucleotide repeats in anovulatory infertility and polycystic ovaries [J].
Mifsud, A ;
Ramirez, S ;
Yong, EL .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (09) :3484-3488
[20]  
*OMIM, 2007, 313700 MIM