Histone modifications in transcriptional regulation

被引：954

作者：

Berger, SL ^{[1
]}

机构：

[1] Wistar Inst, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(02)00279-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Covalent modifications of the amino termini of the core histories in nucleosomes have important roles in gene regulation. Research in the past two years reveals these modifications to consist of phosphorylation, methylation and ubiquitination, in addition to the better-characterized acetylation. This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues persuasively for the existence of a histone code.

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页码：142 / 148

页数：7

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共 63 条

[1] Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter [J].

Agalioti, T ;

Lomvardas, S ;

Parekh, B ;

Yie, JM ;

Maniatis, T ;

Thanos, D .

CELL, 2000, 103 (04) :667-678

[2] Effects of histone acetylation on the equilibrium accessibility of nucleosomal DNA target sites [J].

Anderson, JD ;

Lowary, PT ;

Widom, J .

JOURNAL OF MOLECULAR BIOLOGY, 2001, 307 (04) :977-985

[3] Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain [J].

Bannister, AJ ;

Zegerman, P ;

Partridge, JF ;

Miska, EA ;

Thomas, JO ;

Allshire, RC ;

Kouzarides, T .

NATURE, 2001, 410 (6824) :120-124

[4] Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases [J].

Barlev, NA ;

Liu, L ;

Chehab, NH ;

Mansfield, K ;

Harris, KG ;

Halazonetis, TD ;

Berger, SL .

MOLECULAR CELL, 2001, 8 (06) :1243-1254

[5] SAGA is an essential in vivo target of the yeast acidic activator Gal4p [J].

Bhaumik, SR ;

Green, MR .

GENES & DEVELOPMENT, 2001, 15 (15) :1935-1945

[6] Recruitment of HAT complexes by direct activator interactions with the ATM-related tra1 subunit [J].

Brown, CE ;

Howe, L ;

Sousa, K ;

Alley, SC ;

Carrozza, MJ ;

Tan, S ;

Workman, JL .

SCIENCE, 2001, 292 (5525) :2333-2337

[7] A transcriptively active complex of APP with Fe65 and histone acetyltransferase Tip60 [J].

Cao, XW ;

Südhof, TC .

SCIENCE, 2001, 293 (5527) :115-120

[8] Stimulation of CREB binding protein nucleosomal histone acetyltransferase activity by a class of transcriptional activators [J].

Chen, CJ ;

Deng, Z ;

Kim, AY ;

Blobel, GA ;

Lieberman, PM .

MOLECULAR AND CELLULAR BIOLOGY, 2001, 21 (02) :476-487

[9] Regulation of transcription by a protein methyltransferase [J].

Chen, DG ;

Ma, H ;

Hong, H ;

Koh, SS ;

Huang, SM ;

Schurter, BT ;

Aswad, DW ;

Stallcup, MR .

SCIENCE, 1999, 284 (5423) :2174-2177

[10] Synergistic coupling of histone H3 phosphorylation and acetylation in response to epidermal growth factor stimulation [J].

Cheung, P ;

Tanner, KG ;

Cheung, WL ;

Sassone-Corsi, P ;

Denu, JM ;

Allis, CD .

MOLECULAR CELL, 2000, 5 (06) :905-915

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