Sequence variation in a newly identified HLA-B35-restricted epitope in the influenza a virus nucleoprotein associated with escape from cytotoxic T lymphocytes

被引：100

作者：

Boon, ACM

de Mutsert, G

Graus, YMF

Fouchier, RAM

Sintnicolaas, K

Osterhaus, ADME

Rimmelzwaan, GF

机构：

[1] Erasmus Univ, Inst Virol, NL-3015 GE Rotterdam, Netherlands

[2] Numico Res BV, NL-6700 CA Wageningen, Netherlands

[3] Bloodbank Rotterdam, Lab Histocompatibil & Immunogenet, NL-3318 AS Dordrecht, Netherlands

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 05期

关键词：

D O I：

10.1128/JVI.76.5.2567-2572.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza A virus (H3N2) nucleoprotein, which was found to exhibit a high degree of variation at nonanchor residues. The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity.

引用

页码：2567 / 2572

页数：6

共 35 条

[1] CYTOTOXIC T-LYMPHOCYTE RESPONSE TO A WILD-TYPE HEPATITIS-B VIRUS EPITOPE IN PATIENTS CHRONICALLY INFECTED BY VARIANT VIRUSES CARRYING SUBSTITUTIONS WITHIN THE EPITOPE
BERTOLETTI, A
COSTANZO, A
CHISARI, FV
LEVRERO, M
ARTINI, M
SETTE, A
PENNA, A
GIUBERTI, T
FIACCADORI, F
FERRARI, C
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (03) : 933 - 943
[2] NATURAL VARIANTS OF CYTOTOXIC EPITOPES ARE T-CELL RECEPTOR ANTAGONISTS FOR ANTIVIRAL CYTOTOXIC T-CELLS
BERTOLETTI, A
SETTE, A
CHISARI, FV
PENNA, A
LEVRERO, M
DECARLI, M
FIACCADORI, F
FERRARI, C
[J]. NATURE, 1994, 369 (6479) : 407 - 410
[3] The magnitude and specificity of influenza A virus-specific cytotoxic T-lymphocyte responses in humans is related to HLA-A and -B phenotype
Boon, ACM
de Mutsert, G
Graus, YMF
Fouchier, RAM
Sintnicolaas, K
Osterhaus, ADME
Rimmelzwaan, GF
[J]. JOURNAL OF VIROLOGY, 2002, 76 (02) : 582 - 590
[4] Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus
Borrow, P
Lewicki, H
Wei, XP
Horwitz, MS
Peffer, N
Meyers, H
Nelson, JA
Gairin, JE
Hahn, BH
Oldstone, MBA
Shaw, GM
[J]. NATURE MEDICINE, 1997, 3 (02) : 205 - 211
[5] Unusually high frequency of Epstein-Barr virus genetic variants in Papua New Guinea that can escape cytotoxic T-cell recognition: Implications for virus evolution
Burrows, JM
Burrows, SR
Poulsen, LM
Sculley, TB
Moss, DJ
Khanna, R
[J]. JOURNAL OF VIROLOGY, 1996, 70 (04) : 2490 - 2496
[6] Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus
Chang, KM
Rehermann, B
McHutchison, JG
Pasquinelli, C
Southwood, S
Sette, A
Chisari, FV
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (09) : 2376 - 2385
[7] IMPAIRED CYTOTOXIC T-LYMPHOCYTE RECOGNITION DUE TO GENETIC VARIATIONS IN THE MAIN IMMUNOGENIC REGION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS-1 NEF PROTEIN
COUILLIN, I
CULMANNPENCIOLELLI, B
GOMARD, E
CHOPPIN, J
LEVY, JP
GUILLET, JG
SARAGOSTI, S
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (03) : 1129 - 1134
[8] HLA-A11 EPITOPE LOSS ISOLATES OF EPSTEIN-BARR-VIRUS FROM A HIGHLY A11+ POPULATION
DECAMPOSLIMA, PO
GAVIOLI, R
ZHANG, QJ
WALLACE, LE
DOLCETTI, R
ROWE, M
RICKINSON, AB
MASUCCI, MG
[J]. SCIENCE, 1993, 260 (5104) : 98 - 100
[9] T-CELL RESPONSES AND VIRUS EVOLUTION - LOSS OF HLA A11-RESTRICTED CTL EPITOPES IN EPSTEIN-BARR-VIRUS ISOLATES FROM HIGHLY A11-POSITIVE POPULATIONS BY SELECTIVE MUTATION OF ANCHOR RESIDUES
DECAMPOSLIMA, PO
LEVITSKY, V
BROOKS, J
LEE, SP
HU, LF
DICKINSON, AB
MASUCCI, MG
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (04) : 1297 - 1305
[10] An HLA-B35-restricted epitope modified at an anchor residue results in an antagonist peptide
Dong, T
Boyd, D
Rosenberg, W
Alp, N
Takiguchi, M
McMichael, A
RowlandJones, S
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (02) : 335 - 339

← 1 2 3 4 →