Environmental toxicology:: polychlorinated biphenyls impair TNF-α release in vitro

被引：6

作者：

Ahne, W ^{[1
]}

Jarre, T ^{[1
]}

机构：

[1] Univ Munich, Fac Med Vet, D-80539 Munich, Germany

来源：

JOURNAL OF VETERINARY MEDICINE SERIES A-PHYSIOLOGY PATHOLOGY CLINICAL MEDICINE | 2002年 / 49卷 / 02期

关键词：

D O I：

10.1046/j.1439-0442.2002.jv406.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Tumour necrosis factor (TNF-alpha) was induced by bacterial lipopolysaccharides (LPS)/phytohemagglutin (PHA) stimulated human whole blood in vitro. Levels of TNF-alpha were evaluated by enzyme-linked immunosorbent assay. Blood samples treated with polychlorinated biphenyls (PCB 77, PCB 126) exhibited impairment of TNF-alpha. release: 50 pg/mul PCB reduced by up to 66% and 500 pg/mul PCB reduced by up to 93% the TNF-alpha release compared with the controls.

引用

页码：105 / 106

页数：2