Inflammation and Cancer - II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy

被引：290

作者：

Macarthur, M ^{[1
]}

Hold, GL ^{[1
]}

El-Omar, EM ^{[1
]}

机构：

[1] Univ Aberdeen, Inst Med Sci, Dept Med & Therapeut, Aberdeen AB25 2ZD, Scotland

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2004年 / 286卷 / 04期

关键词：

chronic inflammation; carcinogenesis; reactive oxygen species; cyclooxygenase-2; cytokines; cytokine polymorphisms;

D O I：

10.1152/ajpgi.00475.2003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

It is well established that cancer arises in chronically inflamed tissue, and this is particularly notable in the gastrointestinal tract. Classic examples include Helicobacter pylori-associated gastric cancer, hepatocellular carcinoma, and inflammatory bowel disease-associated colorectal cancer. There is growing evidence to suggest that this association is not coincidental but may indeed be causal. In this review, we discuss the role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy and outline some of the possible mechanisms involved.

引用

页码：G515 / G520

页数：6

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