Stabilization of G-quadruplex DNA and inhibition of telomerase activity by square-planar nickel(II) complexes

被引：317

作者：

Reed, Julie E.

Arnal, Anna Arola

Neidle, Stephen ^{[1
]}

Vilar, Ramon

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 1AZ, England

[2] Univ London, Sch Pharm, CRUK Biomol Struct Grp, London WC1N 1AX, England

[3] Inst Chem Res Catalonia ICIQ, Tarragona 430070, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 18期

关键词：

D O I：

10.1021/ja058509n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new alkylamine-substituted nickel(II)-salphen complexes have been prepared and their interactions with DNA investigated. FRET studies have shown that these complexes have a remarkable ability to stabilize G-quadruplex DNA. Furthermore, TRAP/Taq assays have shown that these complexes inhibit telomerase at low micromolar concentrations. Copyright © 2006 American Chemical Society.

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页码：5992 / 5993

页数：2

相关论文

共 25 条

[1] The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function [J].

Burger, AM ;

Dai, FP ;

Schultes, CM ;

Reszka, AP ;

Moore, MJ ;

Double, JA ;

Neidle, S .

CANCER RESEARCH, 2005, 65 (04) :1489-1496

[2] G-quartets 40 years later:: From 5′-GMP to molecular biology and supramolecular chemistry [J].

Davis, JT .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (06) :668-698

[3] Porphyrin derivatives for telomere binding and telomerase inhibition [J].

Dixon, IM ;

Lopez, F ;

Estève, JP ;

Tejera, AM ;

Blasco, MA ;

Pratviel, G ;

Meunier, B .

CHEMBIOCHEM, 2005, 6 (01) :123-132

[4] Structure of a G-quadruplex-ligand complex [J].

Haider, SM ;

Parkinson, GN ;

Neidle, S .

JOURNAL OF MOLECULAR BIOLOGY, 2003, 326 (01) :117-125

[5] Parallel-stranded guanine quadruplex interactions with a copper cationic porphyrin [J].

Keating, LR ;

Szalai, VA .

BIOCHEMISTRY, 2004, 43 (50) :15891-15900

[6] Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics - current status and future prospects [J].

Kelland, LR .

EUROPEAN JOURNAL OF CANCER, 2005, 41 (07) :971-979

[7] G-quadruplex DNA as a target for drug design [J].

Kerwin, SM .

CURRENT PHARMACEUTICAL DESIGN, 2000, 6 (04) :441-471

[8] Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex [J].

Kim, MY ;

Vankayalapati, H ;

Kazuo, S ;

Wierzba, K ;

Hurley, LH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (10) :2098-2099

[9] SPECIFIC ASSOCIATION OF HUMAN TELOMERASE ACTIVITY WITH IMMORTAL CELLS AND CANCER [J].

KIM, NW ;

PIATYSZEK, MA ;

PROWSE, KR ;

HARLEY, CB ;

WEST, MD ;

HO, PLC ;

COVIELLO, GM ;

WRIGHT, WE ;

WEINRICH, SL ;

SHAY, JW .

SCIENCE, 1994, 266 (5193) :2011-2015

[10] Biological activity of the G-quadruplex ligand RHPS4 (3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration [J].

Leonetti, C ;

Amodei, S ;

D'Angelo, C ;

Rizzo, A ;

Benassi, B ;

Antonelli, A ;

Elli, R ;

Stevens, MFG ;

D'Incalci, M ;

Zupi, G ;

Biroccio, A .

MOLECULAR PHARMACOLOGY, 2004, 66 (05) :1138-1146