Epileptogenesis and rational therapeutic strategies

被引：34

作者：

Stefan, H

da Silva, FHL

Löscher, W

Schmidt, D

Perucca, E

Brodie, MJ

Boon, PAJM

Theodore, WH

Moshé, SL

机构：

[1] Univ Erlangen Nurnberg, Neurol Clin, Epilepsy Ctr, D-91054 Erlangen, Germany

[2] Univ Amsterdam, Ctr Neurosci, Swammerdam Inst Life Sci, Amsterdam, Netherlands

[3] Univ Vet Med, Dept Pharmacol Toxicol & Pharm, Hannover, Germany

[4] Ctr Syst Neurosci, Hannover, Germany

[5] Epilepsy Res Grp, Berlin, Germany

[6] IRCCS, Inst Neurol, C Mondino Fdn, Pavia, Italy

[7] Univ Pavia, Clin Pharmacol Unit, Dept Internal Med & Therapeut, I-27100 Pavia, Italy

[8] Univ Glasgow, Epilepsy Unit, Glasgow, Lanark, Scotland

[9] Ghent Univ Hosp, Dept Neurol, Reference Ctr Refractory Epilepsy, B-9000 Ghent, Belgium

[10] NINDS, Clin Epilepsy Sect, NIH, Bethesda, MD 20892 USA

[11] Albert Einstein Coll Med, Dept Neurol, Montefiore Med Ctr, New York, NY USA

[12] Albert Einstein Coll Med, Dept Neurosci & Pediat, Montefiore Med Ctr, New York, NY USA

[13] Albert Einstein Coll Med, Comprehens Epilepsy Management Ctr, Montefiore Med Ctr, New York, NY USA

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2006年 / 113卷 / 03期

关键词：

epileptogenesis; rational treatment; neurobiological mechanisms; molecular biology; evidence;

D O I：

10.1111/j.1600-0404.2005.00561.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The understanding of neurobiological mechanisms of epileptogenesis is essential for rational approaches for a possible disease modification as well as treatment of underlying causes of the epilepsies. More effort is necessary to translate results from basic investigations into new approaches for clinical research and to better understand a relationship with findings from clinical studies. The following report is a condensed synapsis in which molecular mechanisms of epileptogenesis, pharmacological modulation of epileptogenesis, evidence based therapy, refractoriness and prediction of outcome is provided in order to stimulate further collaborative international research.

引用

页码：139 / 155

页数：17

共 92 条

[1] Epilepsy and the immune system [J].

Aarli, JA .

ARCHIVES OF NEUROLOGY, 2000, 57 (12) :1689-1692

[2] Translating monotherapy trials into clinical practice: a look into the abyss [J].

Arroyo, S ;

Perucca, E .

EPILEPSY & BEHAVIOR, 2003, 4 (05) :457-463

[3] THE RISK OF SEIZURE RECURRENCE FOLLOWING A 1ST UNPROVOKED SEIZURE - A QUANTITATIVE REVIEW [J].

BERG, AT ;

SHINNAR, S .

NEUROLOGY, 1991, 41 (07) :965-972

[4] Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG? [J].

Binnie, CD .

LANCET NEUROLOGY, 2003, 2 (12) :725-730

[5] Spatial stability over time of brain areas generating fast ripples in the epileptic rat [J].

Bragin, A ;

Wilson, CL ;

Engel, J .

EPILEPSIA, 2003, 44 (09) :1233-1237

[6] Seizure-associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy [J].

Briellmann, RS ;

Berkovic, SF ;

Syngeniotis, A ;

King, MA ;

Jackson, GD .

ANNALS OF NEUROLOGY, 2002, 51 (05) :641-644

[7] Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy [J].

Brooks-Kayal, AR ;

Shumate, MD ;

Jin, H ;

Rikhter, TY ;

Coulter, DA .

NATURE MEDICINE, 1998, 4 (10) :1166-1172

[8] A RANDOMIZED STUDY OF CARBAMAZEPINE VERSUS NO MEDICATION AFTER A 1ST UNPROVOKED SEIZURE IN CHILDHOOD [J].

CAMFIELD, P ;

CAMFIELD, C ;

DOOLEY, J ;

SMITH, E ;

GARNER, B .

NEUROLOGY, 1989, 39 (06) :851-852

[9]

CHANDRA B, 1992, CLIN NEUROL NEUROSUR, V94, pS61

[10]

Das CP, 2000, NEUROL INDIA, V48, P357

← 1 2 3 4 5 6 7 8 9 10 →