Regulation of T-helper-cell lineage development by osteopontin: the inside story

被引：130

作者：

Cantor, Harvey ^{[1
,2
]}

Shinohara, Mari L. ^{[3
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Immunol & AIDS, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[3] Duke Univ, Med Ctr, Dept Immunol, Durham, NC 27710 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2009年 / 9卷 / 02期

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; COLLAGEN-INDUCED ARTHRITIS; CENTRAL-NERVOUS-SYSTEM; BOVIS-BCG INFECTION; DENDRITIC CELLS; INTRACELLULAR OSTEOPONTIN; AUTOIMMUNE ENCEPHALOMYELITIS; RHEUMATOID-ARTHRITIS; BORRELIA-BURGDORFERI; MULTIPLE-SCLEROSIS;

D O I：

10.1038/nri2460

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Studies of osteopontin (OPN)-dependent regulation of immune responses have focused on the cytokine activities of the secreted form of this protein. Recent evidence has revealed that an intracellular form of OPN expressed by dendritic cells regulates the expression of pro-inflammatory cytokines and the differentiation of T helper (T-H)-cell lineages. In this Opinion article, we discuss the properties of both OPN isoforms and their respective contributions to the immune response. We propose that cell-type-specific expression of secreted and intracellular OPN regulates the development of distinct effector T-H cells, including that of T(H)1 and T(H)17 cells.

引用

页码：137 / 141

页数：5

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