Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine

被引:24
作者
Miranda, FJ
Alabadi, JA
Lloréns, S
de Apodaca, RFR
Centeno, JM
Alborch, E
机构
[1] Univ Valencia, Fac Farm, Dept Fisiol, E-46100 Valencia, Spain
[2] Hosp La Fe, Ctr Invest, E-46009 Valencia, Spain
关键词
endothelium; diabetes; nitric oxide (NO); 5-HT; (5-hydroxytryptamine; serotonin); cyclooxygenase; renal artery; rabbit;
D O I
10.1016/S0014-2999(02)01438-3
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The influence of diabetes on the response of isolated rabbit renal arteries to 5-hydroxytryptamine (5-HT) was examined. 5-HT induced a concentration-related contraction that was hi-her in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal did not significantly modify 5-HT contractions in arteries from control rabbits but enhanced the response to 5-HT in arteries from diabetic rabbits. Incubation with N-G-nitro-L-arginine (L-NA) enhanced contractions to 5-HT in arteries from control and diabetic rabbits. In arteries with endothelium, this L-NA enhancement was lower in diabetic rabbits than in control rabbits. In arteries without endothelium, incubation with L-NA enhanced the maximal contractions to 5-HT in control rabbits but did not in diabetic rabbits. Indomethacin inhibited 5-HT-induced contraction of arteries from control rabbits and enhanced the maximal contraction to 5-HT of arteries from diabetic rabbits. In summary, diabetes enhances contractile response of rabbit renal artery to 5-HT. In control animals, this response is regulated by both endothelial and non-endothelial (neuronal) nitric oxide (NO) and by a vasoconstrictor prostanoid. Diabetes impairs the release of non-endothelial NO and the vasoconstrictor prostanoid. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:121 / 127
页数:7
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