Synaptic function of cholinergic-specific chol-1α ganglioside

被引：18

作者：

Ando, S ^{[1
]}

Tanaka, Y

Kobayashi, S

Fukui, F

Iwamoto, M

Waki, H

Tai, T

Hirabayashi, Y

机构：

[1] Tokyo Metropolitan Inst Gerontol, Neuronal Funct Res Grp, Div Neurosci & Brain Funct, Itabashi Ku, Tokyo 1730015, Japan

[2] Tokyo Metropolitan Inst Med Sci, Dept Tumor Immunol, Bunkyo Ku, Tokyo 113, Japan

[3] RIKEN, Brain Sci Inst, Frontier Res Program, Neuronal Circuit Membrane Res Grp, Wako, Saitama 35101, Japan

来源：

NEUROCHEMICAL RESEARCH | 2004年 / 29卷 / 04期

关键词：

choline uptake; acetylcholine synthesis; ganglioside; memory; learning;

D O I：

10.1023/B:NERE.0000018860.75734.a7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The function of a cholinergic-specific ganglioside, Chol-1alpha, was investigated. The release of acetylcholine from synaptosomes was inhibited by anti-Chol-1alpha monoclonal antibody but not by monoclonal antibodies against other brain gangliosides tested. Chol-1alpha ganglioside stimulated the high-affinity choline uptake by synaptosomes and consequently enhanced acetylcholine synthesis, resulting in an increased release of acetylcholine from synaptosomes. The memory and learning abilities of rats given anti-Chol-1alpha antibody were remarkably suppressed. These in vitro and in vivo studies suggest that Chol-1alpha ganglioside plays a pivotal role in cholinergic synaptic transmission and participates in cognitive function.

引用

页码：857 / 867

页数：11

共 54 条

[21] FURTHER STUDY OF ROLE OF CALCIUM IN SYNAPTIC TRANSMISSION [J].

KATZ, B ;

MILEDI, R .

JOURNAL OF PHYSIOLOGY-LONDON, 1970, 207 (03) :789-&

[22] Effects of enriched environments with different durations and starting times on learning capacity during aging in rats assessed by a refined procedure of the Hebb-Williams maze task [J].

Kobayashi, S ;

Ohashi, Y ;

Ando, S .

JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 70 (03) :340-346

[23] DIFFERENTIAL DISTRIBUTION OF MAJOR GANGLIOSIDES IN RAT CENTRAL-NERVOUS-SYSTEM DETECTED BY SPECIFIC MONOCLONAL-ANTIBODIES [J].

KOTANI, M ;

KAWASHIMA, I ;

OZAWA, H ;

TERASHIMA, T ;

TAI, T .

GLYCOBIOLOGY, 1993, 3 (02) :137-146

[24] GENERATION OF A MONOCLONAL-ANTIBODY SPECIFIC FOR A NEW CLASS OF MINOR GANGLIOSIDE ANTIGENS, GQ1B-ALPHA AND GT1A-ALPHA - ITS BINDING TO DORSAL AND LATERAL HORN OF HUMAN THORACIC CORD [J].

KUSUNOKI, S ;

CHIBA, A ;

HIRABAYASHI, Y ;

IRIE, F ;

KOTANI, M ;

KAWASHIMA, I ;

TAI, T ;

NAGAI, Y .

BRAIN RESEARCH, 1993, 623 (01) :83-88

[25] The role of GM1 and other gangliosides in neuronal differentiation - Overview and new findings [J].

Ledeen, RW ;

Wu, GS ;

Lu, ZH ;

Kozireski-Chuback, D ;

Fang, Y .

SPHINGOLIPIDS AS SIGNALING MODULATORS IN THE NERVOUS SYSTEM, 1998, 845 :161-175

[26] BIOLOGY OF GANGLIOSIDES - NEURITOGENIC AND NEURONOTROPHIC PROPERTIES [J].

LEDEEN, RW .

JOURNAL OF NEUROSCIENCE RESEARCH, 1984, 12 (2-3) :147-159

[27] EFFECTS OF COMBINED MUSCARINIC AND NICOTINIC BLOCKADE ON CHOICE ACCURACY IN THE RADIAL-ARM MAZE [J].

LEVIN, ED ;

MCGURK, SR ;

SOUTH, D ;

BUTCHER, LL .

BEHAVIORAL AND NEURAL BIOLOGY, 1989, 51 (02) :270-277

[28] CHOLINERGIC MANIPULATIONS IN THE MEDIAL SEPTAL AREA - AGE-RELATED EFFECTS ON WORKING-MEMORY AND HIPPOCAMPAL ELECTROPHYSIOLOGY [J].

MARKOWSKA, AL ;

OLTON, DS ;

GIVENS, B .

JOURNAL OF NEUROSCIENCE, 1995, 15 (03) :2063-2073

[29]

Marquina G, 1996, CANCER RES, V56, P5165

[30] INHIBITION OF HIGH-AFFINITY CHOLINE UPTAKE IN THE RAT-BRAIN BY NEUROTOXINS - EFFECT OF MONOSIALOGANGLIOSIDE GM1 [J].

MAYSINGER, D ;

LEAVITT, BR ;

ZORC, B ;

BUTULA, I ;

FERNANDES, LG ;

RIBEIRODASILVA, A .

NEUROCHEMISTRY INTERNATIONAL, 1992, 20 (03) :289-297

← 1 2 3 4 5 6 →