The COP9 signalosome: Mediating between kinase signaling and protein degradation

被引:44
作者
Harari-Steinberg, O [1 ]
Chamovitz, DA [1 ]
机构
[1] Tel Aviv Univ, Dept Plant Sci, IL-69978 Tel Aviv, Israel
关键词
D O I
10.2174/1389203043379792
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The COP9 Signalosome (CSN), a highly conserved eight-subunit complex, is found in all higher eukaryotes. It contains eight core subunits, named CSN1 - 8, in order of decreasing molecular weight. The CSN is structurally similar to the regulatory lid of 26S proteasome and the eukaryotic translation initiation factor eIF3. CSN is also now known to play an essential role in signaling processes controlling many aspects of plant and Drosophila development. Taken together, the various genetic studies demonstrate that the CSN is involved at the nexus between multiple signal inputs and a variety of downstream regulatory cascades controlling specific aspects of cellular differentiation. Research in various organisms has converged onto the notion that CSN is biochemically linked to ubiquitin-dependent protein degradation. Other proposed roles for the CSN include regulating eIF3 and kinase signaling. CSN is itself is both a target for kinase activity and associates with and coordinates activity of kinases. CSN-associated kinases. This kinase activity further regulates the ubiquitin-dependent degradation of various transcription factors. This review concentrates on the proposed activity of the CSN as a regulator of protein phosphorylation.
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页码:185 / 189
页数:5
相关论文
共 51 条
[1]  
Azevedo C, 2002, SCIENCE, V14, P14
[2]   COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system [J].
Bech-Otschir, D ;
Kraft, R ;
Huang, XH ;
Henklein, P ;
Kapelari, B ;
Pollmann, C ;
Dubiel, W .
EMBO JOURNAL, 2001, 20 (07) :1630-1639
[3]  
Bech-Otschir D, 2002, J CELL SCI, V115, P467
[4]   The COP9 signalosome is an essential regulator of development in the filamentous fungus Aspergillus nidulans [J].
Busch, S ;
Eckert, SE ;
Krappmann, S ;
Braus, GH .
MOLECULAR MICROBIOLOGY, 2003, 49 (03) :717-730
[5]   The COP9 signalosome [J].
Chamovitz, DA ;
Glickman, M .
CURRENT BIOLOGY, 2002, 12 (07) :R232-R232
[6]  
COHEN H, 2000, J BIOL CHEM
[7]  
COPE GA, 2002, SCIENCE, V15, P15
[8]   Unified nomenclature for the COP9 signalosome and its subunits: an essential regulator of development [J].
Deng, XW ;
Dubiel, WG ;
Wei, N ;
Hofmann, K ;
Mundt, K ;
Colicelli, L ;
Kato, J ;
Naumann, M ;
Segal, D ;
Seeger, M ;
Glickman, M ;
Chamovitz, DA ;
Carr, A .
TRENDS IN GENETICS, 2000, 16 (05) :202-203
[9]   The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis [J].
Doronkin, S ;
Djagaeva, I ;
Beckendorf, SK .
DEVELOPMENTAL CELL, 2003, 4 (05) :699-710
[10]   Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor [J].
Dunn, C ;
Wiltshire, C ;
MacLaren, A ;
Gillespie, DAF .
CELLULAR SIGNALLING, 2002, 14 (07) :585-593