Metabolic Actions of Insulin-Like Growth Factor-I in Normal Physiology and Diabetes

被引：275

作者：

Clemmons, David R. ^{[1
]}

机构：

[1] Univ N Carolina, Sch Med, Dept Med, Div Endocrinol, Chapel Hill, NC 27599 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2012年 / 41卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Fat metabolism; Growth; Insulin resistance; Growth hormone; FACTOR-BINDING PROTEIN-3; C-REACTIVE PROTEIN; IMPROVES GLYCEMIC CONTROL; ACID-LABILE SUBUNIT; IGF-I; MUSCLE INSULIN; GLUCOSE-INTOLERANCE; LIPID-METABOLISM; OBESE SUBJECTS; GENE DELETION;

D O I：

10.1016/j.ecl.2012.04.017

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Insulin-like growth factor-I (IGF-I) is closely related to insulin but has distinct metabolic actions. IGF-I is an important stimulant of protein synthesis in muscle, but it also stimulates free fatty acid use. The administration of IGF-I to patients with extreme insulin resistance results in improvement in glycemic control, and IGF-I is associated with lowering glucose and enhancing insulin sensitivity in Type 1 and Type 2 diabetes. However, patients with diabetes are also sensitive to stimulation of side effects in response to IGF-I. IGF-I coordinately links growth hormone and insulin actions and has direct effects on intermediary metabolism.

引用

页码：425 / +

页数：21

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