Atrial Natriuretic Peptide and Adiponectin Interactions in Man

被引:70
作者
Birkenfeld, Andreas L. [1 ,2 ]
Boschmann, Michael [2 ]
Engeli, Stefan [4 ]
Moro, Cedric [3 ]
Arafat, Ayman M. [1 ]
Luft, Friedrich C. [2 ]
Jordan, Jens [4 ]
机构
[1] Charite Univ Sch Med Berlin, CCR, Dept Endocrinol Diabet & Nutr, Berlin, Germany
[2] Expt & Clin Res Ctr, Berlin, Germany
[3] Univ Toulouse 3, Inst Metab & Cardiovasc Dis, Inserm UMR1048, F-31062 Toulouse, France
[4] Hannover Med Sch, Inst Clin Pharmacol, D-3000 Hannover, Germany
来源
PLOS ONE | 2012年 / 7卷 / 08期
关键词
CHRONIC HEART-FAILURE; LIPID MOBILIZATION; HUMAN ADIPOCYTES; ADIPOSE-TISSUE; ASSOCIATION; EXPRESSION; HUMANS; RISK; GENE;
D O I
10.1371/journal.pone.0043238
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Reduced circulating natriuretic peptide concentrations are independently associated with insulin resistance and type 2 diabetes, while increased natriuretic peptide levels appear to be protective. Observations in vitro and in heart failure patients suggest that atrial natriuretic peptide (ANP) promotes adiponectin release, an adipokine with insulin sensitizing properties. We tested the hypothesis that ANP acutely raises adiponectin levels in 12 healthy men. We infused ANP intravenously over 135 minutes while collecting venous blood and adipose tissue microdialysates at baseline and at the end of ANP-infusion. We obtained blood samples at identical time-points without ANP infusion in 7 age and BMI matched men. With infusion, venous ANP concentrations increased similar to 10 fold. Systemic and adipose tissue glycerol concentrations increased 70% and 80%, respectively (P<0.01). ANP infusion increased total adiponectin 14 +/- 5% and high molecular-weight (HMW)-adiponectin 13 +/- 5% (P<0.05). Adiponectin did not change in the control group (P<0.05 vs. infusion). ANP-induced changes in HMW adiponectin and adipose tissue lipolysis were directly correlated with each other, possibly suggesting a common mechanism. Our data show that ANP acutely increases systemic total and HMW-adiponectin concentrations in healthy subjects. Our study could have implications for the physiological regulation of adiponectin and for disease states associated with altered natriuretic peptide availability.
引用
收藏
页数:4
相关论文
共 21 条
[1]   Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans [J].
Birkenfeld, AL ;
Boschmann, M ;
Moro, C ;
Adams, F ;
Heusser, K ;
Franke, G ;
Berlan, M ;
Luft, FC ;
Lafontan, M ;
Jordan, J .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (06) :3622-3628
[2]   β-Adrenergic and atrial natriuretic peptide interactions on human cardiovascular and metabolic regulation [J].
Birkenfeld, Andreas L. ;
Boschmann, Michael ;
Moro, Cedric ;
Adams, Frauke ;
Heusser, Karsten ;
Tank, Jens ;
Diedrich, Andre ;
Schroeder, Christoph ;
Franke, Gabi ;
Berlan, Michel ;
Luft, Friedrich C. ;
Lafontan, Max ;
Jordan, Jens .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (12) :5069-5075
[3]   Metabolic Actions Could Confound Advantageous Effects of Combined Angiotensin II Receptor and Neprilysin Inhibition [J].
Birkenfeld, Andreas L. ;
Adams, Frauke ;
Schroeder, Christoph ;
Engeli, Stefan ;
Jordan, Jens .
HYPERTENSION, 2011, 57 (02) :E4-E5
[4]   Atrial Natriuretic Peptide Induces Postprandial Lipid Oxidation in Humans [J].
Birkenfeld, Andreas L. ;
Budziarek, Petra ;
Boschmann, Michael ;
Moro, Cedric ;
Adams, Franke ;
Franke, Gabriele ;
Berlan, Michel ;
Marques, Marie A. ;
Sweep, Fred C. G. J. ;
Luft, Friedrich C. ;
Lafontan, Max ;
Jordan, Jens .
DIABETES, 2008, 57 (12) :3199-3204
[5]   Effects of intravenous brain natriuretic peptide on regional sympathetic activity in patients with chronic heart failure as compared with healthy control subjects [J].
Brunner-La Rocca, HP ;
Kaye, DM ;
Woods, RL ;
Hastings, J ;
Esler, MD .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (05) :1221-1227
[6]   Adiponectin gene expression is inhibited by β-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes [J].
Fasshauer, M ;
Klein, J ;
Neumann, S ;
Eszlinger, M ;
Paschke, R .
FEBS LETTERS, 2001, 507 (02) :142-146
[7]   Systemic Fate of the Adipocyte-Derived Factor Adiponectin [J].
Halberg, Nils ;
Schraw, Todd D. ;
Wang, Zhao V. ;
Kim, Ja-Young ;
Yi, James ;
Hamilton, Mark P. ;
Luby-Phelps, Kate ;
Scherer, Philipp E. .
DIABETES, 2009, 58 (09) :1961-1970
[8]   Cardiac Natriuretic Peptides, Obesity, and Insulin Resistance: Evidence from Two Community-Based Studies [J].
Khan, Abigail May ;
Cheng, Susan ;
Magnusson, Martin ;
Larson, Martin G. ;
Newton-Cheh, Christopher ;
McCabe, Elizabeth L. ;
Coviello, Andrea D. ;
Florez, Jose C. ;
Fox, Caroline S. ;
Levy, Daniel ;
Robins, Sander J. ;
Arora, Pankaj ;
Bhasin, Shalender ;
Lam, Carolyn S. P. ;
Vasan, Ramachandran S. ;
Melander, Olle ;
Wang, Thomas J. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (10) :3242-3249
[9]   Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure [J].
Kistorp, C ;
Faber, J ;
Galatius, S ;
Gustafsson, F ;
Frystyk, J ;
Flyvbjerg, A ;
Hildebrandt, P .
CIRCULATION, 2005, 112 (12) :1756-1762
[10]   Control of lipolysis by natriuretic peptides and cyclic GMP [J].
Lafontan, Max ;
Moro, Cedric ;
Berlan, Michel ;
Crampos, Francois ;
Sengenes, Coralie ;
Galitzky, Jean .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2008, 19 (04) :130-137