Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review

被引：448

作者：

Hashida, Ryuki ^{[1
,2
]}

Kawaguchi, Takumi ^{[3
]}

Bekki, Masafumi ^{[1
,2
]}

Omoto, Masayuki ^{[1
,2
]}

Matsuse, Hiroo ^{[1
,2
]}

Nago, Takeshi ^{[1
,2
]}

Takano, Yoshio ^{[4
]}

Ueno, Takato ^{[5
,6
]}

Koga, Hironori ^{[3
,6
]}

George, Jacob ^{[7
,8
]}

Shiba, Naoto ^{[1
,2
]}

Torimura, Takuji ^{[3
,6
]}

机构：

[1] Kurume Univ, Dept Orthoped, Sch Med, Kurume, Fukuoka, Japan

[2] Kurume Univ Hosp, Div Rehabil, Kurume, Fukuoka, Japan

[3] Kurume Univ, Dept Med, Div Gastroenterol, Sch Med, 67 Asahi Machi, Kurume, Fukuoka 8300011, Japan

[4] Int Univ Hlth & Welf, Sch Hlth Sci Fukuoka, Dept Phys Therapy, Enokizu, Okawa, Japan

[5] Asakura Med Assoc Hosp, Div Gastroenterol, Dept Internal Med, Asakura, Japan

[6] Kurume Univ, Liver Canc Div, Res Ctr Innovat Canc Therapy, Kurume, Fukuoka, Japan

[7] Westmead Hosp, Westmead Inst Med Res, Storr Liver Ctr, Westmead, NSW, Australia

[8] Univ Sydney, Sydney, NSW, Australia

来源：

JOURNAL OF HEPATOLOGY | 2017年 / 66卷 / 01期

关键词：

Aerobic training; Resistance training; Exercise energy consumption; Adipokine; Myokine; ADIPOSE-TISSUE LIPOLYSIS; LIFE-STYLE MODIFICATION; SHORT-TERM EXERCISE; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; SKELETAL-MUSCLE; FIBER-TYPE; HEPATOCELLULAR-CARCINOMA; IRISIN; METABOLISM;

D O I：

10.1016/j.jhep.2016.08.023

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background & Aims: Exercise is a first-line therapy for patients with non-alcoholic fatty liver disease (NAFLD). We sought to: 1) summarize effective aerobic and resistance exercise protocols for NAFLD; and 2) compare the effects and energy consumption of aerobic and resistance exercises. Methods: A literature search was performed using PubMed, Web of Science, and Scopas to January 28, 2016. From a total of 95 articles, 23 studies including 24 aerobic and 7 resistance exercise protocols were selected for the summary of exercise protocols. Twelve articles including 13 aerobic and 4 resistance exercise protocols were selected for the comparative analysis. Results: For aerobic exercise, the median effective protocol was 4.8 metabolic equivalents (METs) for 40 min/session, 3 times/week for 12 weeks. For resistance exercise, the median effective protocol was 3.5 METs for 45 min/session, 3 times/week for 12 weeks. Aerobic and resistance exercise improved hepatic steatosis. No significant difference was seen in the duration, frequency, or period of exercise between the two exercise groups; however, %VO2max and energy consumption were significantly lower in the resistance than in the aerobic group (50% [45-98] vs. 28% [28-28], p = 0.0034; 11,064 [6394-21,087] vs. 6470 [4104-12,310] kcal/total period, p = 0.0475). Conclusions: Resistance exercise improves NAFLD with less energy consumption. Thus, resistance exercise may be more feasible than aerobic exercise for NAFLD patients with poor cardiorespiratory fitness or for those who cannot tolerate or participate in aerobic exercise. These data may indicate a possible link between resistance exercise and lipid metabolism in the liver. Lay summary: Both aerobic and resistance exercise reduce hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) with similar frequency, duration, and period of exercise (40-45 min/session 3 times/week for 12 weeks); however, the two forms of exercise have different characteristics. Intensity and energy consumption were significantly lower for resistance than for aerobic exercise. Resistance exercise may be more feasible than aerobic exercise for NAFLD patients with poor cardiorespiratory fitness or for those who cannot tolerate or participate in aerobic exercise. (C) 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

引用

页码：142 / 152

页数：11

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