The induction of p53 and WAF1/CIP1 in chronic lymphocytic leukemia cells treated with 2-chlorodeoxyadenosine

被引：28

作者：

Gartenhaus, RB

Wang, P

Hoffman, M

Janson, D

Rai, KR

机构：

[1] Division of Hematology/Oncology, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 1996年 / 74卷 / 03期

关键词：

induction; p53; WAF1/CIP1; CLL;

D O I：

10.1007/BF01575446

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The treatment of chronic lymphocytic leukemia includes the use of alkylating agents, steroids, and more recently nucleoside analogues. While prior studies have described potential mechanisms of 2-chlorodeoxyadenosine cytotoxicity including the accumulation of DNA strand breaks and induction of apoptosis or programmed cell death, the expression of p53 and its downstream target WAF1/CIP1 have not been examined. In this report we describe the induction of p53 and WAF1/CIP1 in the apoptotic chronic lymphocytic leukemia cells after exposure to 2-chlorodeoxyadenosine.

引用

页码：143 / 147

页数：5

共 25 条

[1] ANTILEUKEMIC AND IMMUNOSUPPRESSIVE ACTIVITY OF 2-CHLORO-2'-DEOXYADENOSINE [J].

CARSON, DA ;

WASSON, DB ;

BEUTLER, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (07) :2232-2236

[2]

COLE SPC, 1986, CANCER CHEMOTH PHARM, V17, P259

[3] P53 GENE DELETION PREDICTS FOR POOR SURVIVAL AND NONRESPONSE TO THERAPY WITH PURINE ANALOGS IN CHRONIC B-CELL LEUKEMIAS [J].

DOHNER, H ;

FISCHER, K ;

BENTZ, M ;

HANSEN, K ;

BENNER, A ;

CABOT, G ;

DIEHL, D ;

SCHLENK, R ;

COY, J ;

STILGENBAUER, S ;

VOLKMANN, M ;

GALLE, PR ;

POUSTKA, A ;

HUNSTEIN, W ;

LICHTER, P .

BLOOD, 1995, 85 (06) :1580-1589

[4] WAF1, A POTENTIAL MEDIATOR OF P53 TUMOR SUPPRESSION [J].

ELDEIRY, WS ;

TOKINO, T ;

VELCULESCU, VE ;

LEVY, DB ;

PARSONS, R ;

TRENT, JM ;

LIN, D ;

MERCER, WE ;

KINZLER, KW ;

VOGELSTEIN, B .

CELL, 1993, 75 (04) :817-825

[5]

FAN SJ, 1994, CANCER RES, V54, P5824

[6]

FENAUX P, 1992, LEUKEMIA, V6, P246

[7] P53 MUTATIONS IN HUMAN LYMPHOID MALIGNANCIES - ASSOCIATION WITH BURKITT-LYMPHOMA AND CHRONIC LYMPHOCYTIC-LEUKEMIA [J].

GAIDANO, G ;

BALLERINI, P ;

GONG, JZ ;

INGHIRAMI, G ;

NERI, A ;

NEWCOMB, EW ;

MAGRATH, IT ;

KNOWLES, DM ;

DALLAFAVERA, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (12) :5413-5417

[8]

GARTENHAUS RB, IN PRESS P NATL ACAD

[9] A SELECTIVE PROCEDURE FOR DNA EXTRACTION FROM APOPTOTIC CELLS APPLICABLE FOR GEL-ELECTROPHORESIS AND FLOW-CYTOMETRY [J].

GONG, JP ;

TRAGANOS, F ;

DARZYNKIEWICZ, Z .

ANALYTICAL BIOCHEMISTRY, 1994, 218 (02) :314-319

[10]

HARPER JW, 1993, CELL, V75, P805

← 1 2 3 →