Hormone replacement therapy and prevention of pressure ulcers and venous leg ulcers

被引：74

作者：

Margolis, DJ

Knauss, J

Bilker, W

机构：

[1] Univ Penn, Sch Med, Dept Dermatol, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

来源：

LANCET | 2002年 / 359卷 / 9307期

关键词：

D O I：

10.1016/S0140-6736(02)07806-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pressure ulcers and venous leg ulcers are common chronic wounds. Oestrogens in the form of hormone replacement therapy (HRT) might have an effect on wound healing, but this possibility has not been studied In detail. Using a case-cohort study including elderly patients in the UK General Practice Research Database, we showed that patients who received HRT were less likely to develop a venous leg ulcer (age-adjusted relative risk 0.65 [95% CI 0.61-0.69]) or a pressure ulcer (0.68 [0.62-0.76]) than those who did not use HRT. Therefore, we believe that HRT could be beneficial for the prevention of these wounds.

引用

页码：675 / 677

页数：3