p53 family in development

被引：44

作者：

Danilova, Nadia ^{[1
]}

Sakamoto, Kathleen M. ^{[2
,3
,4
]}

Lin, Shuo ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Mol Cell & Dev Biol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Jonsson Comprehens Canc Ctr, Matel Childrens Hosp, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Jonsson Comprehens Canc Ctr, Div Hematol Oncol,Dept Pediat,Gwynne Hazen Cherry, Los Angeles, CA 90095 USA

[4] CALTECH, Div Biol, Pasadena, CA 91125 USA

来源：

MECHANISMS OF DEVELOPMENT | 2008年 / 125卷 / 11-12期

关键词：

p53; p63; p73; Differentiation; Proliferation; Congenital abnormalities;

D O I：

10.1016/j.mod.2008.09.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The p53 family network is a unique cellular processor that integrates information from various pathways and determines cellular choices between proliferation, replication arrest/repair, differentiation, senescence, or apoptosis. The most studied role of the p53 family is the regulation of stress response and tumor suppression. By removing damaged cells from the proliferating pool, p53 family members preserve the integrity of the genome. In addition to this well recognized role, recent data implicate the p53 protein family in a broader role of controlling cell proliferation, differentiation and death. Members of the p53 protein family with opposing activity perform coordination of these processes. Imbalance of p53 protein family may contribute to a significant proportion of congenital developmental abnormalities in humans. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：919 / 931

页数：13

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